Background: Chronic haemodialysis patients present a lack of immunity responsible for a high incidence of tuberculosis of atypical and non-pulmonary localizations. Observation: We present a clinical case of a haemodialysis patient that presents an isolated localisation of prostate tuberculosis. He had no clinical signs but had laboratory findings of inflammatory syndrome and high Prostatic Antigen (PSA) level. The diagnosis was made by histopathologic study of the piece of prostatectomy. The patient received a six-month treatment with an initial two-month phase involving four anti-tuberculosis drugs (Rifampicin, Isoniazid, Ethambutol and Pyrazinamid) followed by a four-month maintenance phase involving two drugs (Isoniazid and Rifampicin). All drugs were adapted to his dialysis condition. We noticed no side effects of drugs. Conclusion: Clinical signs of prostatic tuberculosis are not specific, mainly made of an obstructive symptom. The diagnosis of prostatic tuberculosis is based on a bundle of clinical and biological arguments. Koch Bacilli (KB) can rarely be found in urine or sperm. In haemodialysis patient, it can be masked by non specific aspect of inflammatory syndrome. The management must be adjusted and a close following up of side effects is necessary.
Chronic haemodialysis patients present a reduced immunity responsible for a high incidence of tuberculosis. Clinical presentation is often atypical and non-pulmonary localisations are not uncommon. However, isolated prostate tuberculosis, as in the general population, remains exceptional. We report the case of a patient undergoing chronic heamodialysis who had an isolated prostate tuberculosis discovered incidentally during his renal transplant checkup.
Mr. E. M aged 52 years, of middle income level, of a Moroccan origin, is followed in our unit as a candidate for renal transplant. He is a former smoker with polycystic kidney disease undergoing hemodialysis since 2008.
The general condition of the patient was preserved and the renal pre-transplant workup revealed a high C Reactive Protein (CRP): 30 mg/l, without leukocytosis or lymphopenia. The Prostatic Specific Antigen (PSA) was high at 7 ng/ml. The bacteriologic analysis of urine found leukocytes without any growth and specificaly no Koch Bacilli (KB) in the urine. Digital rectal examination revealed a soft prostate, homogeneous and non tender.
Prostate MRI showed a left peripheral nodule of 8 × 6 mm. We carried out prostate biopsy but the histopathologic study had not been able to differanciate prostate carcinoma from prostate tuberculosis. In the context of renal transplant project, no other paraclinical exploration has been made and a radical prostatectomy has been carried out. The histopathologic study was in favor of an epithelioid and giant-cell granulomatous prostatitis with caseous necrosis that allowed us to retain the diagnosis of prostate tuberculosis.
There was no sexual transmitted infection, and the serology for Human Immunodeficiency Virus was negative. The search of another tuberculosis location, particularly pulmonary, urinary or bone location, was negative. Our patient received a six-month treatment with an initial two-month phase involving four anti-tuberculosis drugs (Rifampicin, Isoniazid, Ethambutol and Pyrazinamid) followed by a four-month maintenance phase involving two drugs (Isoniazid and Rifampicin).
The evolution after one year was marked by the absence of the inflammatory syndrome, of high PSA rate and leukocytes rate in urine. The patient had maintained postoperative urinary incontinence, cured after multiple bladder rehabilitation sessions.
Renal transplant was allowed 12 months after the end of the treatment and the patient has been placed on the national list of candidates for renal transplant by brain-dead donor.
In the general population, isolated prostate tuberculosis is rare. Some cases are described in the literature. Between 1989 and 2004, during a Moroccan study, Bensouda et al. noted of 22 patients with genital tuberculosis only one case of prostatic tuberculosis [
For patients undergoing chronic hemodialysis, the risk of tuberculosis infections has a prevalence of 9.43% [
Tuberculosis infection of the prostate is primarily hematogenous, and not necesarly associated with urinary lesions. Nevertheless a sexual transmission is possible and has been described. The hypothesis of dissemination after BCG therapy has also been reported [
Rectal examination often shows an increase in prostate volume, with an elastic, firm, nodular or stony consistency. PSA level [
Histology responds to two mechanisms. Cavities are formed by the caseus and end up by creating perineal fistulas. Fibrosis, limiting the extension of the lesions, is responsible for the clinical signs of obstruction such as dysuria and pollakiuria [
The treatment of tuberculosis in the dialysis patient must be adapted to the dialysis conditions. The treatment duration is the same as in subjects with normal renal function.
This treatment should involve several antituberculosis drugs, in two phases, with a regular single intake on an empty stomach in the morning, for a sufficient duration, 06 months. The pattern adopted according to the resistance profiles comprises the association of Isoniazid (I), Rifampicin (R), Pyrazinamide (P) and Ethambutol (E) [
The Monitoring of residual levels of anti-tuberculosis drugs can be performed for optimal dose adaptation in the hemodialysis patient.
The treatment toxicity is more pronounced in dialysis patients compared with patients not yet on dialysis. Hepatic and neurological toxicities are the most
Creatinin clearance (ml/min) | Rifampicin | Isoniazid | Ethambutol | Pyrazinamid | Rifabutin | |
---|---|---|---|---|---|---|
>50 kg | <50 kg | |||||
60 - 30 | 10 mg/kg/day | 3 to 5 mg/kg/day | 20 mg/kg/day | 30 mg/kg/2 days | 300 mg/day | 450 mg/2 days |
30 - 15 | 10 mg/kg/day | 3 to 5 mg/kg/day | 20 mg/kg/2 days | 30 mg/kg/2 days | 300 mg/day | 450 mg/2 days |
<15 et HD | 10 mg/kg/day Non dialyzable | 3 to 5 mg/kg/day Dialysable | 20 mg/kg/2 days Dialysable | 30 mg/kg/2 days Dialysable | 150 mg/day Non dialysable | 150 mg/day Non dialysable |
CAPD | 10 mg/kg/day | 3 to 5 mg/kg/day | 20 mg/kg/2 days | 30 mg/kg/2 days | ND | ND |
HD: Haemodialysis, CAPD: Continuous Ambulatory Peritoneal Dialysis, ND: Non Disponible.
Molecules | Interval between taking and dosing (hour) | Target serum concentrations (mg/l) | Concentration requiring therapeutic adjustment (mg/l) |
---|---|---|---|
Ethambutol | 2 - 3 | 2 - 6 | <2 |
Rifampicin | 2 | 8 - 24 | <6 |
Isoniazid | 1-2 | 3 - 6 | <2 |
Pyrazinamid | 1-2 | 20 - 40 | <15 |
encountered. Neurological toxicity is efficiently prevented by the addition of systematic Pyridoxine to the dosage of 10 to 50 mg/kg/day. Liver fonction test must be performed at least monthly to detect a cytolysis or cholestasis that will require therapeutic facilities.
We did not notice any side effects of the treatment given to our patient.
Tuberculosis in dialysis patients has specific aspects concerning both the diagnosis and the treatment.
Atypical forms are not uncommon. In the face of any alteration of the general condition or inflammatory syndrome, even insidious of the dialysis patients, the diagnosis of tuberculosis must be mentioned.
The implementation of adequate therapy requires the monitoring of side effects that could involve the patient’s vital and/or functional prognosis.
I confirm that the patient had given his consent for the Case reports to be published.
The authors declare that they have no conflict of interest.
Koné, M.H., Fares, I., Houem, I., Benamar, L., Ouzeddoun, N., Bayahia, R. and Bouattar, T. (2019) Tuberculosis of Exceptional Location in a Haemodialysis Patient. Open Journal of Nephrology, 9, 35-39. https://doi.org/10.4236/ojneph.2019.91004