Objective: To explore the application value of electrocardiograph (ECG) T-wave Alternans (TWA) anomaly in acute stage of intracerebral hemorrhage patients. Methods: We choose 1175 intracerebral hemorrhage patients whose conventional 12-lead ECG has TWA in our hospital from January 2011 to December 2015, 751 patients without TWA in the same period as the control group, compared the volume of intracerebral hemorrhage, bleeding site and mortality between the 2 groups. Results: In TWA group, 247 cases died, 361 cases with massive intracerebral hemorrhage, 298 cases with brain stem hemorrhage; in TWA negative group (control group), 41 cases died, 93 cases with massive brain hemorrhage, 64 cases with brain stem hemorrhage. There are statistical differences between two groups (P < 0.05). Multi factor Logistic regression analysis showed that massive intracerebral hemorrhage, brain stem hemorrhage, Glasgow score and TWA were the independent factors in the prognosis of intracerebral hemorrhage (P < 0.05). Conclusion: The occurrence of TWA is significantly related to the volume of bleeding, the bleeding site and mortality, and can be used as an important parameter in the prognosis of intracerebral hemorrhage.
Intracerebral hemorrhage is a disease with high mortality. In cerebrovascular events, the ECG often changes, which is related to the high mortality of intracerebral hemorrhage. It can provide useful clues to the doctors to assess a patient and judge the prognosis. In addition to the general severity index, another indicator TWA, such as the S-T changes, severe arrhythmia and so on, can be a sign of myocardial repolarization abnormalities. Although we discussed the relationship between TWA and cerebral hemorrhage site and hemorrhage volume of 65 cases [
First, 2417 intracerebral hemorrhage patients in our hospital were selected from January 2011 to December 2015, all patients were diagnosed as intracerebral hemorrhage by CT, excluding patients who had coronary heart disease (typical angina symptoms and ECG changes, or cardiac angiography evidence), arrhythmia (ECG changes), electrolyte disturbance (typical clinical symptom and blood electrolyte examination), cardiac hypertrophy (cardiac color ultrasound evidence), and used anti-arrhythmia drugs and digoxin drugs (patients readme). The remaining 1926 patients, including 1039 males and 887 females, aged 34 - 91 years, average age (61.27 ± 21.23) years. Among them, 1175 patients with the TWA were the experimental group, including 634 males and 541 females, aged 39 - 91 years, the average age (63.75 ± 20.17) years, Glasgow score (9.1 ± 2.1), of which 286 patients died, Glasgow score (7.9 ± 1.8); the remaining 751 patients as control group, including 405 males and 346 females, aged 34 to 87 years, average age (60.32 ± 22.74) years, Glasgow score (12.3 ± 4.1). There were no significant differences in age and sex between the two groups (P > 0.05). The basic information between the experimental group and the control group is showed in
1) The Bleeding volume calculation: by coniglobus formula [
Total | Average age | Gender male female | Glasgow score | ||
---|---|---|---|---|---|
The experimental group | 1175 | 63.75 ± 20.17 | 634 | 541 | 9.1 ± 2.1 |
The control group | 751 | 60.32 ± 22.74 | 405 | 346 | 12.3 ± 4.1 |
P value | P > 0.05 | P > 0.05 | P > 0.05 |
ml are massive hemorrhage, the rest is not.
2) All intracerebral hemorrhage patients synchronous scanned routine 12-lead ECG examination on the 1st day in hospital. TWA calculation: the same lead T- wave amplitude difference 0.1 mv is TWA, calculate the incidence of TWA.
Intracerebral hemorrhage site, intracerebral hemorrhage volume and mortality between the two groups were compared by the χ2 test, using multiple factors logistic regression analysis to determine the independent predictive factor of prognosis, P < 0.05 has a statistically significant difference.
1) In 1926 brain hemorrhage patients, 1175 cases with TWA, the occurrence rate was 61.0%, 454 cases with massive brain hemorrhage, accounting for 23.6%, 1472 cases without massive Intracerebral hemorrhage, accounting for 76.4%; 96 cases with lobe hemorrhage, accounting for 5%; 1272 cases with basal ganglia hemorrhage, accounting for 66.0%; 173 cases with cerebellar hemorrhage, accounting for 9% and 362 cases with brain stem hemorrhage, accounting for 18.8%, 23 cases with intraventricular hemorrhage, accounting for 1.2%; 286 cases died, accounting for 14.8%.
2) Compared with the control group, in the experimental group, the patients with massive intracerebral hemorrhage, brain stem hemorrhage and death rate were statistically significant (P < 0.01), as showed in
3) Multivariate logistic regression analysis showed that massive intracerebral hemorrhage, brain stem hemorrhage, Glasgow score and TWA were the independent factors in the prognosis of intracerebral hemorrhage (P < 0.05).
Intracerebral hemorrhage is a disease of high death rate and high disability rate [
Total | The experimental group | The control group | X2 value | P value | |
---|---|---|---|---|---|
Massive intracerebral hemorrhage | 454 | 361 | 93 | 85.539 | <0.01 |
Brain stem hemorrhage | 362 | 298 | 64 | 85.125 | <0.01 |
Death | 288 | 247 | 41 | 87.247 | <0.01 |
Total | 1104 | 906 | 198 |
drugs and digoxin drugs are excluded. We only analyze the influence on cardiac repolarization by intracerebral hemorrhage, and find an independent predictor of the prognosis with intracerebral patients hemorrhage. Because cardiac death is always caused by ventricular arrhythmias, and the influence of intracerebral hemorrhage on cardiac repolarization is obvious [
We retrospectively analyzed all patients who were hospitalized in our hospital from January 2011 to December 2015. The patients who had coronary heart disease, arrhythmia, electrolyte disorder, cardiac hypertrophy, and the use of anti-arrhythmia drugs and digoxin drugs were excluded. There were 1926 patients, in which 1175 patients had TWA on the conventional 12-lead ECG on the first day of admission, accounting for 61%. There was a great difference between the reported normal healthy people [
The mechanism that intracerebral hemorrhage induces TWA is not very clear. Studies have found that the increase of sympathetic nerve tension can induce TWA, sympathetic nervous excitement makes the action potential morphology and amplitude change, thus inducing ventricular repolarization heterogeneity and leading to TWA. Therefore, we speculate that the mechanism of TWA in intracerebral hemorrhage is mainly caused by affecting the autonomic nervous function, which leads to the dysfunction of the sympathetic and parasympathetic. Autonomic nerve cortical representation known to regulate cardiac activity is in the orbital surface of the frontal lobe and the anterior cingulate cortex (i.e. 13 and 24 districts), and hypothalamus as a higher subcortical autonomic nerve center, regulates the cardiac activity. The insular lobe is closely related to the occurrence of TWA. Brain stem as the descending pathway of autonomic nerve, also has an important effect on the cardiac activity. So we speculate that massive intracerebral hemorrhage on the basal ganglia and lobes affect the autonomic nerve center of cingulate, insular lobe and hypothalamus. The brain stem hemorrhage can directly destroy autonomic nerve descending pathway, causing the change of autonomic nerve center and the imbalance of sympathetic and parasympathetic and affecting of cardiac conduction system and myocardial repolarization, producing TWA and leading to the occurrence of ventricular arrhythmia, but the specific mechanism needs to be further confirmed in our later experiments.
Our study has some limitations. First of all, a variety of other prognostic factors for intracerebral hemorrhage have been studied. However, in different models it is difficult to be fully taken into account, it may cause some deviation. We should try to judge comprehensively in the future analysis. Second, autonomic nerve dysfunction could be studied by other methods, such as the change of blood pressure and heart rate variability, but these studies need to observe for a long time and special analysis software, but our purpose is to provide a fast and effective prediction index to the grassroots medical staff, so we choose TWA, hoping to replace the application of heart rate variability and blood pressure changes. In short, TWA occurrence is an independent predictor of intracerebral hemorrhage patients’ hospitalized death, TWA occurrence reminds that intracerebral hemorrhage patients have severe autonomic dysfunction and brain damage, these patients should get more attention in the follow-up treatment.
We thank the hospital medical records department’s support in providing ECG information.
Li, X. and Cheng, X.L. (2017) Application of T-Wave Alternans in Evaluation of Prognosis in Patients with Intracerebral Hemorrhage. Yangtze Medicine, 1, 127-132. https://doi.org/10.4236/ym.2017.13013