An enormous development is experimented on the porous materials. The porous was considered a defect on solid materials some years ago, but right now, this defect is an advantage, based on the properties obtained from a micro and mesoporous materials. Microporous, mesoporous and macroporous materials with an uniformed pore distribution offer new properties, such as absorption, adsorption, exchange separation, and catalysis of different compounds, also they can play different roles as hosts for a nanocomposite materials to modify or improve their properties. Today, the structural types of open framework porous compounds have rapidly increased by their unique structural properties, porous size window and accessible void space are critical factors on a medical application.
Immense research during the last decade has been devoted to adjust the morphology (the size and shape) of solids at various length scales from the nanometer to the micrometer scale [
Porous materials are classified by the pore size; the International Union of Pure and Applied Chemistry (IUPAC) classify the porous materials in:
・ Microporous, materials have pore diameters of less than 2 nm;
・ Mesoporous, materials have pore diameters between 2 nm and 50 nm;
・ Macro porous, materials have pore diameters of greater than 50 nm.
Microporous, Mesoporous and Macro porous materials can be manufactured using many substances such as carbon, silicon, silicates, ceramics, minerals and polymers (silicone) (
The application of porous materials is of great interest in various fields of medicine like:
o Implants;
o Drug delivery;
o Sensors;
o Membranes;
o Filters;
o Catheters;
o Valves;
o Prosthesis;
o Scaffolds;
o etc.
Biocompatible implants allow the human body to restore the biological and mechanical functions; therefore manage to increase the quality of life. Depending on the biomedical application, the implant has to withstand mechanical loads, while conducting a long term biological interaction with the surrounding biological tissue is promoted. Bulk properties of the implant are primarily responsible for the load bearing capacities, where the interaction with the surrounding tissue is governed by the implant surface [
Silica based mesoporous materials have been extensively proposed for different biomedical applications, such as ceramics for bone regeneration, because these materials exhibit high surface areas and pore volumes, tunable and narrow pore size distributions and these are easily functionalized. These properties allow the materials to act as host matrices for active molecules (drugs, peptides, proteins, etc.) [
The organic biomaterials with a porous structure have flexible nature with multiple control function that made them attractive for many advanced applications such as sensing, medical uses, and selective material conversion. Immobilization of biocompounds into organized structures paid much attention. However, most of them have difficulty in mechanical stability, and some of them have difficulty in material diffusion and unsuitability to make contact with artificial devices. Unlike these materials, inorganic porous materials have several advantages as media for biomaterial immobilization:
・ They are mechanically much stronger;
・ The diffusion of materials should be ensured in mesopore spaces;
・ High flexibility in fabrication (shapes and sizes);
・ The hybridized surface possibility on mesoporous materials increases the adsorption and absorption pro- perties.
The combination of porous organic materials with inorganic materials is a developed research, and these products are actually base on the upstanding properties for specific applications. Direct substitution of component elements in original porous materials, with maintaining structural regularity, provided novel properties that could be applied on surgical implants [
The discovery of ordered porous materials and the wide range of used materials to obtain these, like silica, metal oxides, and sulfides open great field applications on nanoscience. Organic-inorganic hybrids play an important role in the design application; the siloxane and organosiloxane have been used to prepare hybrid porous materials with functional groups at their surface [
Fibrovascular ingrowth into porous implants offers the potential for excellent prosthesis movement, and also reduces a chance of infection, exposure, and displacement, porous polyethylene, silicon, aluminum oxide have been used. Silicone is a material being used in medical science for variety of prosthetic applications, because of its excellent biocompatibility and low cost, some limitations of silicone are limited ingrowth but it can be improve with the introduction of functional groups or nanoparticles in its surface [
The applications of porous based materials as a potential drug delivery system have grown exponentially, in particular in the field of oral drug delivery vehicles to improve dissolution properties of hydrophobic drug molecules, and thus, there is a great need for drug delivery systems capable of improving the physicochemical properties [
Porous silica and silicon have been studied with promising results on drug delivery systems [
The continuous researching labor on porous materials developed a variety of approaches for many applications of this material in the industrial area and most important on the medical field. Metal-organic (hybrids) frameworks also show promising properties, although this structure combine with organic functionalities can enhance the range of applications to more realistic conditions than pure inorganic mesoporous materials. Pure inorganic mesoporous materials have their intrinsic limitations lacking both functionalities and mechanical strength [
A key issue in biotechnology is the stabilization of biological active molecules under non-physiological conditions, as their tendency to lose activity in artificial environments. Immobilization onto inert inorganic materials may cope with stability and compatibility problems, thus favoring advance in technological applications. The success of such a strategy depends on proper selection of the hybrid materials that can support or host the bioactive components while maintaining its activity and selectivity [
・ Adsorption profiles of insulin on porous materials and release profiles of insulin entrapped on folded sheet mesoporous silica were study with successful results. The amount of adsorbed insulin, estimate by protein assay increased with an increase in the pore sizes, and the release of the drug could be controlled by varying the pore size, also the encapsulation of the insulin may have potential to avoid enzymatic degradation [
・ Porous silica impregnated with anticancer drug (doxorubicin) is another research area, sorption and desorption of the drug is investigated. Dexorubicin is an anthracycline cytostatic antibiotic with against a wide range of human cancers application, but its use is limited by the toxicity side effects, to reduce this limitation and improve delivery to tumor site, various targeted drug delivery systems such, liposomes, nanoparticles, polymer micelles and porous materials are evaluate [
・ Metalloproteins has attracted considerable attention for applications in mediator-free biosensors. Hemoglobin, a heme protein that stores and transports oxygen, consists of four polypeptides with a redox behavior, it is a large protein matrix, that makes it difficult to establish direct electron transfer between hemoglobin and conventional electrodes, but the immobilization of this redox protein on mesoporous material can be avoid this issue, and it represents a promising applications on a biological fields, for a novel biosensors development [
・ The porous materials functionalized with mercaptopropyl and vinyl groups showed greater adsorption capacity and good release behavior for rhodamine 6G molecules. On the other hand, the porous matrices that contain amine functional groups showed greater adsorption capacity and better release properties for ibuprofen molecules. Improved adsorption and release properties of porous materials by simple changes of functional groups on the porous channels walls are the key for drug delivery systems [
Poor aqueous solubility is acknowledged as one of the major barriers in the development of novel pharma- ceutical agents. More than 40% of newly identified lead compounds are lipophilic, resulting in poor pharma- cokinetic properties, insufficient dissolution, unfavorable drug-drug interactions, poor drug absorption and bioavailability, which leads to need high dosing to reach therapeutic levels in blood. Organic and inorganic nanomaterials are currently being studied as drug delivery vehicles, to achieve supersaturation in the gastro-intestinal environment. Mesoporous materials have emerged as suitable excipients with a complete set of desirable properties in comparison to traditional formulation strategies relay on administering poor water soluble drugs as a solution or emulsion in present of surfactants or complex agents [
Implants for topical delivery of drugs like corticosteroids or antibiotics are a novel approach to manage post- surgical complications associated to inflammation or infections. A controlled release drug delivery consists of two basic components, that is, a biologically active agent and the drug carrier, the system has numerous advantages over conventional forms of dosage:
・ Maintaining the patient blood level;
・ Minimizing deleterious side effects;
・ Prolonging efficiency time;
・ Heightening bioavailability;
・ Protecting sensitive drugs from enzymatic or acidic degradation;
・ Helps to maintain the drug on biological fluids within a desired therapeutic range;
・ Deliver the drug locally to specific site;
・ Avoid possible toxicity;
・ Increase patient compliance and comfort;
・ Decreasing the dosing, and frequency [
Silicone rubber (PDMS) is well-known polymeric material frequently used to develop drug delivery devices, along with its customary medical applications such as parts in cardiac pacemaker leads, mammary prostheses, drainage implants in glaucoma, temporary skin substitutes, blood oxygenators, medical adhesives, finger joints, and catheters [
The porous materials have diverse range of applications such medical imaging, drug delivery, implants, or sensors. The used of porous silicone on the medical field achieving a sharp technologies that can increase the quality human life, though surface modification this porous material can combine hydrophobicity properties inside the pores, silicone surface could be obtain with an etching process and later it is possible to introduce and join reactive functional groups on the porous silicon surface to obtain special properties. The different internal surfaces on porous materials impart different physical properties, a surface modified with the hydrophobic functional groups avoids the water ingress inside the pores, in contrast if the functional groups are hydrophilic the water passes, and the material is filled with water [
Noninvasive imagine techniques are of foremost relevance diagnostics, diverse imaging modalities are available with porous technology application, such magnetic resonance imaging (MRI) and computed tomography (CT), to those that provide specific molecular imaging such as positron electron tomography (PET) and optical fluorescence.
Contrast agents for a medical imaging diagnostic have to fulfill important prerequisites:
1) Forming stable colloidal solution in vitro and in vivo environments;
2) Chemical stability under physiological conditions;
3) Exhibiting limited nonspecific binding to avoid macrophagocytic system uptake;
4) Having programmed clearance mechanisms;
5) Showing high sensitivity and selectivity for target;
6) Good image contrast;
7) Having relatively long circulation time in the blood if administered intravenously.
In this sense porous material based contrast agents are promising platforms to meet the aforementioned prerequisites [
Many nanosized particles systems are being developed as intravascular carriers to increase the levels of therapeutic agents delivered to targets, the surface of these carriers is often functionalized with biological recognition molecules for specific barriers in the body that prevent these carriers from localizing at their targets at sufficiently high therapeutic concentrations. Multistage delivery system can carry, release over time and deliver two types of nanoparticles into primary endothelial cells, multistage system is based on biodegradable and biocompatible porous silicone particles the included therapeutic drug and imaging contrast agents [
Nanoparticles have become more prevalent in reports of novel contrast agents, especially for molecular imaging, the detection of cellular process. The advantages of nanoparticles include their potency to generate contrast, the ease of integrating multiple properties, lengthy circulation times, and the possibility to include high payloads. With this technology and the used of micropores, mesopores and macropores materials, more sophisticated examples of contrast agents have been reported, such as paramagnetic, macrophage, targeted quantum dots, MRI visible micro-emulsions, etc. the used of this technology is producing a greater knowledge of diseases process and effects of therapy [
The use of computational models in the design of sensors is an increasing area of interest, in their design two main issues have be taken into account to model the behavior: on one hand the interaction between recognition agent and analyte and the signal transduction, in this work porous membrane are explore with a successful results. Micro, meso and macroporous systems have been presented in different formats as a potential tool or framework for detection analytes or by simple using a common property to all molecules or recognition agents (label sensors) [
Many studies have been carried out for early diagnosis of complex diseases by finding accurate, robust and stable biomarkers specific to diseases. In particular, recent rapid advance of high-throughput technologies provides unprecedented rich information to characterize various disease genotypes and phenotypes, also a new acknowledge about nanoscience, micro and mesoporous materials accelerates significantly the study of biomarkers from both theoretical and clinical perspectives [
Porous materials were utilized to immobilize enzymes, their huge area, modifiable surface, and restricted spaces generated synergistic effects that enhance enzyme stability, improve product selectivity, and facilitate separation and reuse of enzymes. The immobilized property of molecules and enzymes on pores materials can be applied as viable biocatalysts and pharmaceutical industries on medical applications for a drug delivery, imaging, sensors, implants, etc [
The poly dimethylsiloxane (PDMS) have gaining popularity base on its possibility to made micro and mesoporous frameworks that can stabilize functional groups and nanoparticles with a special properties the can be used for biological applications, their non-toxicity, easy fabrication, scalability, optical transparency, and low cost potentially all recently research. The surface modification methods developed for a micro and mesoporous PDMS material can improve the repelling properties (hydrophobicity) and open the way too easily and strongly interactions between the base material and biological molecules, organs and tissues, this improvement on PDMS surface permits the porous PDMS use on biological analysis, such as biomolecule separation, immunoassay, cell culture and DNA hybridization [
The currently, standard methods for diseases detection require expensive and bulky instruments, and they have associated delays, and lack of selectivity. In order to solve these problems, recent efforts have been directed toward the development of biological methods of detection combined with physical transducers (biosensors). In particular, amperometric biosensors with an immobilized enzyme on a porous matrix can offer high sensitivity, high selectivity and short response time without requiring a complicated instrumentation [
Nanoscience and nanotechnology produce a revolution on the medical field and biological science because application of unique characteristics from the combine of micro, meso, macroporous and nanoparticles has been expanding on animal and human help procedures like sensing, imaging, cell targeting, drug delivery, etc, because cells can readily uptake nanoparticles from these systems.
Micro and mesoporous materials are high performance materials in their own right, for instance as catalysts highly selective absorbents, but addition they provide excellent opportunities for the creation of materials with additional functionality. Their pore system can be used to introduce molecules or particles that are stabilized by the solid framework [
Most of porous materials are mainly microporous and this makes them well-suited for many applications on a medical industry. However, there are numerous potential applications in which materials with pores would be advantageous. Therefore, the control of the textural and structural properties of porous materials is one of the main subjects because they are very important for certain applications [
The use of micro, meso and macroporous material can be a very practical approach to reaching several goals in current medical applications like surgical implants, drug delivery, medical imaging, biological sensors, and others. Their performance under ambient conditions, mechanically and thermally strong under harsh conditions is the key. The hybridization of supporting materials and the combination of polymers and inorganic materials with a porous structure have been proposed to attain both biological and mechanical requirements.
Porous materials have been either organic or inorganic, inorganic solids such as silicas and metal oxides are usually crystalline but organic solids such as activated carbon is amorphous or partially ordered like graphite or diamond. In contrast ordered porous, organic-inorganic hybrid materials such as organosilicas, combine the respective beneficial characters of organic and inorganic components but also exhibit exceptional properties with enormous opportunities for medical applications in drug delivery, imaging and other medical applications [
Great progresses in structure control and functionalization of porous materials have been achieved for biotechnological and biomedical applications. Silica-based controlled drug delivery systems, magnetism and/or luminescence, functionalized systems, which integrated targeting and tracking abilities of molecules, stimuli-res- ponsive controlled release systems that are able to respond to environmental changes, such as pH, redox potential, temperature, photoirradiation, etc, have been achieved [
The porous materials, their size control, density, channel connectivity, the roughness and functionalization of the surface are the keys for an enormous and future application, the medicine field is included in this movement, the new medical device design is compared with a building construction where you can control the room size, quantity, connected aisles and the materials for the walls, all of these, based on the used or application that you can give.
The researchers will be the nano-architects of the future porous structures that support new developments and applications on the medical field.
VictorSolano-Umaña,José RobertoVega-Baudrit, (2015) Micro, Meso and Macro Porous Materials on Medicine. Journal of Biomaterials and Nanobiotechnology,06,247-256. doi: 10.4236/jbnb.2015.6423