| Clinicopathological factors | Variables | Postoperative adjuvant chemotherapy | P-value | |
| Present (n = 162) | Absent (n = 72) | |||
| Age | ≥75 | 15 | 27 | <0.001 |
| <75 | 147 | 45 | ||
| Gender | Male | 96 | 36 | 0.20 |
| Female | 66 | 36 | ||
| Location | Proximal | 51 | 19 | 0.54 |
| Distal | 111 | 53 | ||
| Preoperative CEA | Elevated | 71 | 30 | 0.78 |
| Normal | 91 | 42 | ||
| Differentiation | Low gradea | 151 | 67 | >0.99 |
| High gradeb | 11 | 5 | ||
| Invasion depth | T1 - T3 | 94 | 55 | 0.008 |
| T4 | 68 | 17 | ||
| Lymphatic invasion | None-mild | 46 | 32 | 0.02 |
| Moderate-severe | 116 | 40 | ||
| Venous invasion | None-mild | 79 | 52 | 0.001 |
| Moderate-severe | 83 | 20 | ||
| No. of dissected lymph nodes | ≥12 | 129 | 53 | 0.31 |
| <12 | 33 | 19 | ||
| TNM classification, 7th edition | IIIA, IIIB | 129 | 63 | 0.20 |
| IIIC | 33 | 9 | ||