| Feature | TIGR4 genome | R6 genome |
| Genome size | 2,160,837 bp | 2,038,615 bp |
| G + C content | 39.70% | 40% |
| No. of genes | 2236 | 2043 |
| Capsule | Serotype 4 | 7504 bp deletion |
| Sequence type | 205 | 128 |
| Surface-exposed proteins | ||
| Choline binding | 15 | 10 |
| LPxTG | 19 | 13 |
| Lipoprotein | 47 | 42 |
| Signal peptide | 256 | 153 |
| Repeat elements | ||
| IS elements | 105 | 91 |
| BOX elements | 105 | 115 |
| RUP elements | 111 | 84 |
| tRNA genes | 58 | 58 |
| rRNA genes | 4 | 4 |
| sRNA | 3 | 3 |