Open Journal of Obstetrics and Gynecology
Vol.05 No.01(2015), Article ID:53482,9 pages

Management of Cardiac Pacemakers in a Pregnant Patient

Sonal Grover1, Puja Sheth1, David E. Haines2, Mazhar Khan3, Bernard Gonik1*

1Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, USA

2Department of Cardiovascular Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, USA

3Department of Cardiology, Wayne State University School of Medicine, Detroit, USA

Email: *,

Academic Editor: Christos E. Constantinou, Stanford University Medical School, USA

Copyright © 2015 by authors and Scientific Research Publishing Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY).

Received 5 January 2015; accepted 20 January 2015; published 23 January 2015


Introduction: Despite the increasing use of permanent cardiac pacemakers in a younger patient population, there are little data related to pregnancy. We present our experience in managing a pregnant patient with a pre-existing pacemaker and review the existing literature to establish management guidelines. Case: A 27-year-old G1 P0 presented for prenatal care in the first trimester of pregnancy. She had a past medical history of bradycardia, hypotension and syncope that required dual chamber cardiac pacemaker placement 6 years earlier, and one episode of left upper extremity venous thrombosis related to replacement of the pacemaker wire 4 years earlier. In the early second trimester, the patient began experiencing light-headedness and breathlessness with exertion. The rate settings of the pacemaker were increased with resolution of the patient’s symptoms. The patient underwent primary cesarean section at 39 weeks gestation with delivery of a healthy term infant. Preoperative anesthesia consultation was obtained. The postoperative course was uneventful. Pre-pregnancy pacemaker settings were re-established after the postpartum period. Discussion: The current literature on managing pregnant patients with pre-existing pacemakers is quite limited. Such patients require a multidisciplinary approach to care. Normal physiologic changes in pregnancy may necessitate rate adjustments. Other than routine thromboprophylaxis, no other anticoagulation is needed. Route of delivery is generally based on obstetric indications. During surgery consider using bipolar electrocautery in place of unipolar electrocautery, to reduce electromagnetic interference. Also, the placement of the grounding pad should be as far away from the pacemaker as possible. It should be anticipated that the patient will return to her baseline cardiac status postpartum and therefore pacemaker settings can be adjusted accordingly.


Pacemaker, Pregnancy, Anticoagulants, Fetal Monitoring, Electrocardiography, Anesthesia, Antepartum

1. Introduction

Despite the increasing use of permanent cardiac pacemakers in a younger patient population, there are little data related to pregnancy. Normal physiologic alterations of pregnancy need to be taken into account in the management of the pregnant woman with a pacemaker in place. Similarly, gestational events including the potential for surgical intervention require a basic knowledge of pacemaker technology and monitoring. We present a case of a patient with a pre-existing pacemaker who presented in pregnancy in order to illustrate pertinent issues in this regard.

2. Case Report

A 27-year-old G1 P0 presented for prenatal care in the first trimester of pregnancy. She had a significant past medical history of bradycardia, hypotension and syncope that required permanent DDD cardiac pacemaker placement 6 years earlier. One year after implant, she had failure of both atrial and ventricular leads secondary to lead-to-lead abrasion and insulation failure. The leads were replaced. She had one episode of left upper extremity venous thrombosis related to replacement of the pacemaker wire 4 years ago, that was treated with short term anticoagulation therapy. A thrombophilia work up revealed an MTHFR compound heterozygous gene mutation. No additional anticoagulation was administered. During the pregnancy the patient was placed on prenatal vitamins and folate supplementation. In the early second trimester, the patient began experiencing light-head- edness and breathlessness with exertion. Pacemaker interrogation showed that the pacemaker was programmed in the DDD mode with a low rate of 60 ppm. She was predominantly atrial pacing at 60 ppm with native AV conduction and entricular sensing. Her heart rate histogram showed relative chronotropic incompetence for a pregnant woman (Figure 1). The basal pacing rate was increased to 80 ppm during the day and 70 ppm during sleep, with resolution of the patient’s symptoms. The remainder of the pregnancy progressed unremarkably. The patient underwent primary cesarean section at 39 weeks gestation with delivery of a healthy term infant. Preoperative anesthesia consultation was obtained. The postoperative course was uneventful. Pre-pregnancy pacemaker settings were re-established after the postpartum period.

3. Discussion

An increasing number of women with implanted pacemakers present to their obstetrician contemplating pregnancy or already pregnant. Reasons for this are multifaceted, but include improvements in cardiovascular surgery for congenital heart conditions, advancements in pacemaker technologies, and an expanding database that reassures the health care community that successful pregnancies can be accomplished with minimal adverse consequences [1] . Still, the current literature on this subject is quite limited and incomplete [2] -[4] . Recognizing that care of such patients requires a multidisciplinary approach, the obstetrician-gynecologist should be aware of the basic principles related to the care of these types of patients.

4. Incidence

The most common reason for pacemaker placement in a reproductive aged female patient is sinus node dysfunction followed by atrioventricular (AV) block [5] [6] . Other less common indications include neurocardiogenic syncope and iatrogenic causes such as AV node injury after ablation for supraventricular tachycardia. Figure 2 illustrates the American College of Cardiology/American Heart Association guidelines for implantation of pacemaker [7] .

5. Physiology of Pregnancy

Pregnancy is associated with a variety of cardiovascular physiologic changes that may influence the need for

Figure 1. Histogram representation of time spent in heart rate ranges by deciles. The patient spent 66% of her time at the low rate of the pacemaker (60 - 69 bpm), and rarely exceeded 89 bpm. This indicates chronotropic incompetence, with an inappropriately low heart rate for a pregnant woman.

Figure 2. American College of Cardiology/American Heart Association guidelines for implantation of pacemaker.

pacemaker support, or alter the management of a patient already implanted with such a device. Blood volume normally increases during pregnancy, with an estimated 50% increase from baseline near term [8] . Cardiac output rises during the early weeks in pregnancy to about 30% above non-pregnant levels, and remains there for the duration of the pregnancy [9] . Early on, this is primarily due to an increase in stroke volume, but later is also associated with an increased heart rate. A drop in cardiac output can be demonstrated late in gestation, mainly as a function of reduced venous return due to inferior vena cava compression by the enlarged uterus; left lateral positioning will minimize this effect. Reduced systemic vascular resistance is a regular feature of advancing pregnancy [9] . This presents clinically as a reduction in both systolic and diastolic blood pressure in the middle trimester of pregnancy, with a later return to pre-pregnancy values.

6. Electrocardiographic Changes in Pregnancy

As the pregnancy advances the growing gravid uterus elevates the diaphragm resulting is leftward deviation of the maternal heart in relation to the chest wall. This is reflected on the electrocardiogram (EKG), as shift of QRS axis to the left in the frontal plane [10] . Other EKG changes that have been reported are development of new arrhythmias, frequent sinus tachycardia with accompanying shortened PR and QT intervals, small Q waves and inverted P waves in lead III (abolished by inspiration), increased R/S ratio in leads V1 and V2, sagging of ST segments and inverted or flat T waves in lead III [11] -[15] . Figure 3 summarizes these EKG changes during pregnancy.

7. Pacemaker Technology

Many different types of pacemakers exist today, requiring a basic understanding of this technology. Pacemakers consist of 2 basic parts: the pulse generator, and electrode wires or leads. Permanent pacemaker leads are usually placed transvenously through the cephalic, axillary or subclavian veins. Pacemakers can be programmed externally with radio waves from a pacemaker programmer [16] . The North American Society of Pacing & Electrophysiology (NASPE) and the British Pacing & Electrophysiology Group (BPEG) have jointly established the nomenclature, known as the NBG (NASPE/BPEG Generic) code, to identify the variety of pacemakers (Table 1) [17] . It is based on 5 letters, the first letter denotes the chamber(s) being paced, the second letter refers to the chamber(s) in which sensing occurs, with “A” indicating atrium, “V” ventricle and “D” dual for both atrium and ventricle. The third position refers to the response of the pacemaker to a sensed event. The fourth letter indicates the presence or absence of rate modulation and the fifth letter reflects the potential and location of multisite pacing. The pacemakers are selected based on the specific abnormality present in the individual [1] . Our patient had a dual chamber pacemaker programmed in DDD mode, indicating that both atrial and ventricular chambers

Figure 3. Electrocardiographic changes during normal pregnancy.

Table 1. The Revised NASPE/BPEG generic pacemaker code.

were either sensed or paced if needed. Atrial activity was tracked and in the absence of ventricular activity a ventricular stimulus was delivered.

Further, pacemakers that are rate responsive allow for a pre-programmed adjustment to the heart rate [18] . Our patient had a rate responsive pacemaker, which is advantageous for patients with chronotropic incompetence because of its ability to increase rate in response to exercise, which becomes more vital as the pregnancy advances. Sensors for rate modulation are incorporated in the pacemaker and depending on pacemaker model respond to activity, minute ventilation or a combination of both. The alternative, a fixed rate pacemaker, is programmed at a set rate, and is unable to change with patient activity [18] . Hidaka et al. [19] , reported their experience with fixed-rate pacemakers in pregnant patients and concluded their safe use, mostly because of the increase in stoke volume that occurs if the pacing rate if set correctly. The pacing rates in their study were 70 - 90 beats per minute, but they also stated that the optimal pacing rate was not investigated. Based on the historic literature, if a fixed rate device is used, empiric rates of between 60 to 120 bpm have all been suggested [20] . Today, all modern pacers have rate responsive capabilities. The patient either has rate responsiveness turned on if they are chronotropically challenged, or off if they have intact sinus node function but have a problem like heart block. In that case, the pacer is “rate responsive” in that it tracks sinus rhythm/sinus tachycardia and paces the ventricle.

8. Approach to Antenatal Management

8.1. Role of Preconception Counseling

As some pregnant patients have pacemakers due to congenital heart defects, preconception counseling to discuss fetal risks for cardiac anomalies may need to be employed. It is well established that fetal risk for cardiac anomaly is 2-5 times greater if the affected patient is the mother (Table 2) [21] . Of note, the cardiac anomalies are not always the same as those of the parent. Additionally, some cardiac lesions may be a part of a larger syndromic diagnosis in the parents, and therefore genetic counseling may need to be expanded beyond cardiac concerns [22] . Importantly, several of these conditions have specific genetic markers that can be tested using either chorionic villus or amniocentesis-derived samples. Preconception counseling also allows for a thorough evaluation of the maternal cardiac status, with the opportunity to optimize her condition, preemptively modify pharmacologic agents appropriate for pregnancy, and deal with other comorbidities that may have an effect on pregnancy [23] .

8.2. Management during Pregnancy

Usually patients with pacemakers tolerate the pregnancy well. The few reported maternal complications appeared to be isolated to patients with underlying structural heart disease [24] . Thaman et al. [24] reported their experience with 11 pregnant patients with pacemakers. Three of these patients, who had underlying structural heart disease, developed maternal complications. One patient developed cardiac decompensation in the third trimester and was induced at 38 weeks. The other developed recurrent palpitations secondary to a short run of atrial fibrillation. Both these patients had uneventful deliveries and postpartum courses. The third patient developed progressive right ventricular failure and had an intrauterine fetal death at 20 weeks gestation. Although these data suggest the need for more careful surveillance when a structural heart defect is associated with pacemaker usage, given the very limited nature of these reported events, a firm recommendation cannot be established.

With regard to routine care, co-management with the cardiology service is required. Either before the pregnancy or early in the first trimester, an EKG, echocardiogram and baseline pacemaker interrogation should be done. Device interrogation can provide information about pacemaker dependency. Pacemaker dependent patients may have no or very slow escape rhythms and require extra precautions during surgery. Throughout the pregnancy, attention should be paid to any new onset of symptoms such as palpitations, shortness of breath, syncope, seizure-like activity, dizziness, confusion, and exercise intolerance [25] . It may be difficult to distinguish between normal common pregnancy symptoms and mild degrees of cardiac dysfunction, requiring further evaluation and adjustments in pacing rate. Our patient began experiencing light-headedness and breathlessness with exertion, in the early second trimester. After cardiac evaluation the rate settings of the pacemaker were in creased with resolution of the patient’s symptoms.

Table 2. Recurrence risks for isolated congenital heart defects.

8.3. Use of Anticoagulants

Pregnancy is considered a pro-thrombotic state due to the increase in coagulation factors. Levels of fibrinogen (Factor I), factors VII, VIII, IX, and X all increase by 50% during pregnancy. In addition, activated protein C and S, inhibitors of coagulation, decrease during pregnancy [26] . Despite these recognized physiologic changes in pregnancy, routine anticoagulation is not typically recommended in patients with pacemakers, unless additional risk factors are identified. There have been a few cases of recurrent pulmonary emboli secondary to large thrombi formed along the pacemaker lead reported in the literature [27] [28] . Most of these cases responded well to anticoagulation with heparin when the symptoms presented. There is one reported case where the thrombi did not resolve with anticoagulation treatment, which required interventional cardiac surgery after an uncomplicated delivery [29] . Adequate data are lacking to firmly establish absolute clinical guidelines in the management of the patient with a pacemaker in place. Despite the absence of pharmacologic recommendations, prophylactic measures such as the use of pregnancy-specific support hose and avoiding situations that lead to lower extremity venous stasis should be empirically employed.

In cases where anticoagulation is required, heparin derivatives are preferred over warfarin as these former agents do not cross the placenta [30] . An exception may be in the patient with mechanical valves, where heparin use was associated with a higher incidence of valve thrombosis compared to warfarin [31] . This remains a controversy, and multiple empiric regimens have been suggested in these specific circumstances [32] . In one report, a patient on warfarin with an implanted pacemaker secondary to Ebstein’s anomaly had an intrauterine fetal demise at 20 weeks [24] . The fetal autopsy showed evidence of warfarin embryopathy [4] . Warfarin use beyond 36 weeks of gestation might also be associated with an increased risk of both maternal and fetal hemorrhage [33] .

8.4. Delivery Route

In terms of choosing a vaginal delivery versus a caesarean section for these patients, both methods have been advocated for in case reports [34] [35] . Generally speaking, delivering with a pre-existing pacemaker is a low risk event and not a contraindication for vaginal delivery. The decision regarding route of delivery should be based on the obstetric indications or other co-morbidities associated with the pregnancy [19] [26] .

8.5. Fetal Monitoring

Pacemakers do not interfere with antepartum or intrapartum external fetal heart rate monitoring. This is because these are ultrasonographic modalities that do not compete electronically with the pacemaker device. During labor, internal fetal scalp electrodes are most commonly used to record fetal electrocardiographic signals. The typical fetal scalp electrode has notch filters that eliminate power line interference frequencies above 60 Hz and band-pass filters that omit frequencies <30 Hz and >100 Hz, thus allowing only frequencies between 30 - 50 Hz to be picked [36] [37] . The maternal ECG signals are below 30 Hz [38] and are therefore selectively filtered out by these device features. However, there are some reports where the scalp electrode recorded the pulse from the maternal pacemaker rather than the fetal R wave during intrapartum monitoring. This happens when the maternal pacing artifact has higher voltage than the fetal R wave, as a result, maternal ECG signals instead of fetal R waves are detected by fetal scalp electrode. For this reason, manufacturers of fetal heart rate monitors specifically note that use of their instruments require extra caution during monitoring.

8.6. Anesthesia and Pacemakers

The anesthetic management of a pregnant patient with a pacemaker is also important to consider for delivery management. Anesthesia consultation early during the pregnancy is advised [1] . During the first stage of labor, cardiac output can increase by 12% from the baseline value and increases even further as labor continue. At full cervical dilation cardiac output increases by an average value of 34% [39] . These changes in cardiac output can be attenuated with the use of epidural anesthesia [19] [40] . Further, performing the delivery in the lateral decubitus position is also recommended, as this position reduces rapid hemodynamic fluctuations during bearing down [41] .

In patients undergoing cesarean delivery, the anesthesiologist must be aware of mode of pacing, date of implantation and durability of the pacemaker batteries [42] . He should be able to recognize early signs of reduced cardiac output and any pacemaker dysfunction on ECG. Additionally, any electrolyte imbalance must be corrected before anesthesia as both hypokalemia or hyperkalemia can alter the pacing threshold [43] . While selecting the type of anesthesia for surgery, it is best to avoid any maternal hypotension as it can compromise uteroplacental blood flow [44] . For this reason epidural anesthesia is preferred over spinal anesthesia as latter is more often associated with maternal hypotension and subsequent fetal bradycardia [40] . This especially important in patients with pacemakers who may not generate a tachycardic response to hypotension associated with conduction anesthesia [45] . Baron et al. [46] did not find any difference in maternal heart rate before and after the epidural anesthesia. Further, adequate prior hydration and vasopressors should be used to minimize hemodynamic changes associated with regional anesthesia [42] .

During cesarean delivery, only bipolar electrocautery should be used, and in very short bursts, to avoid interference pacemaker output and inappropriate resetting of the device [47] . Inhibition of output due to interference from electrocautry may lead to asystole in a pacemaker dependent patient. Reprogramming of the pacemaker to an asynchronous mode is protective against electromagnetic interference and is generally only done for pacemaker dependent patients. If changes in pacemaker programming are made before surgery, it is important to program the device back to initial settings after surgery. As a routine precaution, the grounding plate for the cautery system should be placed as close as possible to the operating site, and as far as possible away from the pacemaker [48] [49] . If even after these measures are in place, the pacemaker is still affected by the surgical instrumentation then the pacemaker can be converted to a continuous asynchronous pacing mode (VOO) by programming or by placement of a magnet over the device. The magnet must remain in place over the device to maintain asynchronous mode of pacing.

8.7. Complications and Management

Again, there is limited clinical information regarding adverse pregnancy outcomes associated with pacemaker usage. In one small study [19] , only one patient developed the complication of preeclampsia during the pregnancy. In another case report, a preterm birth at 30 weeks gestation occurred with neonatal acidemia [4] . Lastly, “fetal distress” was reported in a paced gravid patient of unclear etiology, with the subsequent delivery of a healthy infant via cesarean section [34] . None of these cases had similar events, or biologically plausible connections to the pacemakers themselves, suggesting a lack of direct association.

The most common non-obstetrical complication seen with the pacemaker is skin irritation and ulceration at the implantation site due to breast hypertrophy [4] [40] . Therefore, it is important to place the pacemaker in women of reproductive age at a site such as the sub-pectoral region rather then the abdomen or breast areas, which undergo skin changes during pregnancy or may be involved in procedures like cesarean sections. Being mindful of the site of pacemaker placement would also decrease the chance of pacemaker lead dislodgement or fracture, known as Twiddler’s syndrome [19] . Other recognized complications, not specifically linked to pregnancy, include chronic pain, battery failure and extra systole [50] -[52] .

9. Conclusion

Pregnancy in patients with pacemakers is possible but requires a multidisciplinary approach to care. Normal physiologic changes in pregnancy may necessitate antenatal pacing rate adjustments. It may be difficult to distinguish between common pregnancy symptoms and mild degrees of cardiac dysfunction. Other than routine thromboprophylaxis, no other anticoagulation is needed. Pacemaker dependency should be recognized early in pregnancy. Despite cesarean delivery in this case, route of delivery is generally based on obstetric indications. During surgery, bipolar electrocautery should be used to reduce electromagnetic interference and the grounding pad should be placed as far away from the pacemaker as possible. Following the pregnancy, it should be anticipated that the patient would return to her baseline cardiac status and therefore have the pacemaker settings adjusted accordingly.


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*Corresponding author.