
S. Elkhateb et al. / Open Journal of Obstetrics and Gynecology 1 (2011) 221-224
224
on other internal organs. Norifumi Tanaka reported the
case of a patient who presented the BRBNS disease with
the outbreak of several haemangiomas on the uterine
cervix during pregnancy. A Caesarean was carried out.
One month postpartum reduction in the size of the le-
sions was observed. The lesion, induced by pregnancy,
increased during pregnancy and regressed after delivery
[17].
Padmanabhan et al. reported the rare association of ca-
vernous haemangioma of the cervix with the focal no-
dular hyperplasia of the liver in a patient using oral con-
traceptives [19].
Reggiani L et al. present three cases of cervix hae-
mangioma in asymptomatic women, diagnosed as ca-
vernous haemangioma in two cases and capillary hae-
mangioma in one. All tumors were immune-reactive to
CD31, CD34, and factor-VIII-related antigen. Focal ex-
pression of estrogen receptors was detected. No positivi-
ty was obtained with progesterone receptor antibodies.
The presence of estrogen receptor in the cervix haeman-
gioma endothelial cells suggests a direct role of this hor-
mone in haemangioma development. A possible target
therapy is discussed [6].
4. CONCLUSIONS
The uterine cervix cavernous haemangioma is a very
rare pathology in pregnant women. This benign vascular
lesion may cause gynecological-obstetrical complica-
tions. It is recommended to perform a Caesarean. Some-
times, the consequences could also be serious. Although,
delivery by natural ways is possible but Caesarean is
recommended. The differential diagnosis is very difficult
because it is a rare lesion. Uterine atony or disseminated
intravascular coagulation can be observed, likely to lead
to hysterectomy. The final diagnosis can only be made
via the histological study.
REFERENCES
[1] Gupta, R., Singh, S., Nigam, S. and Khurana, N. (2006)
Benign vascular tumors of the female genital tract. In-
ternational Journal of Gynecology Cancer, 16, 1195-1200.
[2] Gusdon, J.P. (1965) Haemangioma of the cervix four new
cases and a review. American Journal of Obstetrics Gy-
necology, 91, 204-209.
[3] Virk, R.K., Zhong, J. and Lu, D. (2008) Diffuse cavern-
ous haemangioma of the uterus in a pregnant woman:
Report of a rare case and review of literature. Archives of
Gynecology and Obstetrics, 279, 603-605.
doi:10.1007/s00404-008-0764-7
[4] Talerman, A. (1967) Hemangioma of the ovary and the
cervix. Obstetrics and Gynecology, 30, 108-113.
[5] Cherkis, R.C. and Kamath, C.P. (1988) Hemangioma of
the uterine cervix and pregnancy: A case report. Journal
of Reproductive Medicine, 33, 393-395.
[6] Reggiani Bonetti, L., Boselli, F., Lupi, M., Bettelli, S.,
Schirosi, L., Bigiani, N., Sartori, G. and Rivasi, F. (2009)
Expression of estrogen receptor in haemangioma of the
uterine cervix: Reports of three cases and review of the
literature. Archives of Gynecology and Obstetrics, 280,
469-472. doi:10.1007/s00404-009-0928-0
[7] Baxi, S. (2005) Capillary haemangioma of the cervix-a
case report. Indian Journal of Pathology and Microbiol-
ogy, 48, 373-375.
[8] Ozyer, S., Uzunlar, O., Gocmen, M., Bal, S., Srvan, L.
and Mollamahmutoğlu, L. (2006) Cavernous hemangio-
ma of the cervix: A rare cause of vaginal bleeding. Jour-
nal of Lower Genital Tract Disease, 10, 107-108.
doi:10.1097/01.lgt.0000210120.78145.b8
[9] Wang, Y.C., Chen, C.H., Su, H.Y., Li, H.S. and Liu, J.Y.
(2005) Huge spindle cell hemangioma of the cervix-mi-
micking a pelvic tumor. Gynecologic and Obstetric In-
vestigation, 60, 98-101. doi:10.1159/000085523
[10] Kondi-Pafiti, A., Kairi-Vassilatou, E., Spanidou-Carvou-
ni, H., Kontogianni, K., Dimopoulou, K. and Goula, K.
(2003) Vascular tumors of the female genital tract: A
clinicopathological study of nine cases. European Jour-
nal of Gynaecological Oncology, 24, 48-50.
[11] Petry, K.U., Bernhards, J. and Jagla, K. (1994) Caver-
nous hemangioma of the uterine cervix in pregnancy.
Geburtshilfe Frauenheilkd, 54, 62-64.
doi:10.1055/s-2007-1023553
[12] Jackson, J. (1993) Natural history of a cervical cavernous
hemangioma through two pregnancies. Journal of the
American Board of Family Practice, 6, 283-287.
[13] Lovett, B.G. and Camden, N.J. (1959) Hemangioma of
uterine cervix complicating pregnancy. American Journal
of Obstetrics and Gynecology, 78, 424.
[14] Poppe, W., Van Assche, F.A., Wilms, G., Favril, A. and
Baert, A. (1987) Pregnancy after transcatrher emboliza-
tion of a uterine arteriovenous malformation. American
Journal of Obstetrics and Gynecology, 156, 1179.
[15] Malhotra, S., Sehgal, A. and Nijhawan, R. (1995) Caver-
nous hemangioma of the uterus. International Journal of
Gynecology and Obstetrics, 51, 159-160.
doi:10.1016/0020-7292(95)02473-P
[16] Enzinger, F.M. and Weiss, S.W. (1995) Soft tissue tu-
mors. Third Edition, The CV Mosby company, St Louis.
[17] Tanaka, N., Tsuda, M., Samura, O., Miyoshi, H., Hara, T.
and Kudo, Y. (2007) Blue rubber bleb nevus syndrome:
Report of a patient with haemangiomas of the vaginal
portion of the cervix appearing during pregnancy. Jour-
nal of Obstetrics and Gynaecology Research, 33, 546
-548. doi:10.1111/j.1447-0756.2007.00568.x
[18] Ahern, J.K. and Allen, N.H. (1978) Cervical heman-
gioma: A case report and review of the literature. Journal
of Reproductive Medicine, 21, 228-231.
[19] Padmanabhan, V., Mount, S.L. and Eltabbakh G.H. (2001)
Cavernous hemangioma of the cervix in association with
focal nodular hyperplasia of the liver: A case report.
Journal of Reproductive Medicine, 46, 1067-1070.
[20] Riggs, J., Bertoni, M., Schiavello, H., Weinstein, A. and
Kazimir, M. (2003) Cavernous hemangioma of the cervix
with intractable bleeding: A case report. Journal of Re-
productive Medicine, 48, 741-743.
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