Association between Sex Differences and the Pharmacokinetics of Repaglinide among a Malaysian Population
336
doi:10.2165/00003088-200241070-00002
[3] C. R. Culy and B. Jarvis, “Repaglinide: A Review of Its
Therapeutic Use in Treatment of Type 2 Diabetes Melli-
tus,” Drugs, Vol. 61, No. 11, 2001, pp. 1625-1660.
doi:10.2165/00003495-200161110-00008
[4] T. B. Bidstrup, I. Bjornsdottir, U. G. Sidelmann, M. S.
Thamsen and K. T. Hansen, “CYP2C8 and CYP3A4 Are
the Principal Enzymes Involved in the Human in Vitro
Biotransformation of the Insulin Secretagogue Repag-
linide,” British Journal of Clinical Pharmacology, Vol.
56, No. 3, 2003, pp. 301-314.
doi:10.1046/j.0306-5251.2003.01862.x
[5] S. Rendic and F. J. Carlo, “Human Cytochrome P450
Enzyme: A Status Report Summarizing Their Reaction,
Substrates, Inducers and Inhibitors,” Drug Metabolism
Reviews, Vol. 29, No. 1-2, 1997, pp. 413-580.
doi:10.3109/03602539709037591
[6] D. Dai, C. Darryl, D. C. Zeldin, J. A. Blasidell, B. Chanas,
S. J. Coulter, et al., ”Polymorphisms in Human CYP2C8
Decrease Metabolism of the Anticancer Drug Paclitaxel
and Arachidonic Acid,” Pharmacogenetics, Vol. 11, No.
7, 2001, pp. 597-607.
doi:10.1097/00008571-200110000-00006
[7] H. Yamazaki, A. Shibata, M. Suzuki, M. Nakajima, N.
Shimada and F. P. Guengerich, “Oxidation of Troglita-
zone to a Quinine-Type Metabolite Catalyzed by Cyto-
crome P450 2C8 and P450 3A4 in Human Liver Micro-
somes,” Drug Metabolism and Disposition, Vol. 27, No.
11, 1999, pp. 1260-1266.
[8] W. Muck, “Clinical Pharmacokinetics of Cerivastatin,”
Clinical Pharmacokinetics, Vol. 39, No. 2, 2000, pp.
99-116. doi:10.2165/00003088-200039020-00002
[9] T. Shimada, H. Yamazaki, M. Mimura, Y. Inui and F. P.
Guengerich, “Interindividual Variations in Human Liver
Cytochrome P450 Enzymes Involved in the Oxidation of
Drugs, Carcinogens and Toxic Chemicals,” Journal of
Pharmacology and Experimental Therapeutics, Vol. 270,
No. 1, 1994, pp. 414-423.
[10] P. B. Watkins, “Non-Invasive Tests of CYP3A4 Enzymes,”
Pharmacogenetics, Vol. 4, No. 4, 1994, pp. 171-184.
doi:10.1097/00008571-199408000-00001
[11] J. Hamilton and B. Parry, “Sex-Related Differences in
Clinical Drug Response: Implications for Women’s Heal-
th,” Journal of the American Medical Women’s Associa-
tion, Vol. 38, No. 5, 1983, pp. 126-132.
[12] G. C. Yee, T. P. Lennon and D. J. Gmur, “Age-Dependent
Cyclosporine: Pharmacokinetics in Marrow Transplant Re-
cipients,” Clinic al Pharmacology & Therapeutics, Vol. 40,
No. 4, 1986, pp. 438-443. doi:10.1038/clpt.1986.204
[13] D. J. Greenbalt, J. S. Harmatz and L. L. von Moltke, “Age
and Gender Effects on the Pharmacokinetics and Pharma-
codynamics of Triazolam, a Cytochrome P450 3A Sub-
strate,” Clinical Pharmacology & Therapeutics, Vol. 76,
No. 5, 2004, pp. 467-479. doi:10.1016/j.clpt.2004.07.009
[14] M. E. Krecic-Shepard, C. R. Barnas, J. Slimko and J. B.
Schwartz, “Faster Clearance of Sustained Release Vera-
pamil in Men versus Women: Continuing Observations
on Sex-Specific Defferencesafter Oral Administration of
Verapamil,” Clinical Pharmacology & Therapeutics, Vol.
68, No. 3, 2000, pp. 286-292.
doi:10.1067/mcp.2000.109356
[15] A. B. Ruzilawati, A. W. Suhaimi, A. Imran, Z. Ismail and S.
H. Gan, “Method Development and Validation of Repag-
linide in Human Plasma by HPLC and Its Application to
Pharmacokinetics Study,” Journal of Pharmaceutical and
Biomedical Analysis, Vol. 43, No. 5, 2007, pp. 1831-1835.
doi:10.1016/j.jpba.2006.12.010
[16] A. B. Ruzilawati, A. W. Mohd Suhaimi and S. H. Gan,
“Genetic Polymorphisms of CYP3A4: CYP3A4*18 Allele
Is Found in Five Healthy Malaysian Subjects,” Clinica
Chimica Acta, Vol. 383, No. 1-2, 2007, pp. 158-162.
doi:10.1016/j.cca.2007.05.004
[17] Y. D. Muthiah, W. L. Lee, L. K. Teh, C. E. Ong, M. Z.
Salleh and R. Ismail, “A Simple Multiplex PCR Method
for the Concurrent Detection of Three CYP2C8 Vari-
ants,” Clinica Chimica Acta, Vol. 349, No. 1-2, 2004, pp.
191-198. doi:10.1016/j.cccn.2004.06.024
[18] A. B. Ruzilawati, A. W. Mohd Suhaimi and S. H. Gan,
“Population Pharmacokinetic Modeling of Repaglinide in
Healthy Subjects by Using Nonparametric Adaptive Grid
(NPAG) Algorithm,” Journal of Clinical Pharmacy and
Therapeutics, Vol. 35, No. 1, 2010, pp. 105-112.
doi:10.1111/j.1365-2710.2009.01042.x
[19] B. Meibohm, I. Beierle and H. Derendorf, “How Important
Are Gender Differences in Pharmacokinetics?” Clinical
Pharmacokinetics, Vol. 41, No. 5, 2002, pp. 329-342.
doi:10.2165/00003088-200241050-00002
[20] S. H. Haidar, S. B. Johnson, M. J. Fossler and A. S. Hus-
sain, “Modeling the Pharmacokinetics and Pharmacody-
namics of a Unique Oral Hypoglycemic Agent Using
Neural Networks,” Pharmaceutical Research, Vol. 19,
No. 1, 2002, pp. 87-91. doi:10.1023/A:1013611617787
[21] R. Z. Harris, L. Z. Benet and J. B. Schwartz, “Gender Ef-
fects in Pharmacokinetics and Pharmacodynamics,” Drugs,
Vol. 50, No. 2, 1995, pp. 222-239.
doi:10.2165/00003495-199550020-00003
[22] W. R. Hutson, R. L. Roehrkasse and A. Wald, “Influence
of Gender and Menopause on Gastric Emptying and Motil-
ity,” Gastroenterology, Vol. 96, No. 1, 1989, pp. 617-629.
[23] F. Abad-Santos, J. Novalbos, M. A. Galvez-Mugica, S.
Gallego-Sandin, S. Almeida and F. Vallee, “Assessment
of Sex Differences in Pharmacokinetics and Pharmaco-
dynamics of Amlodipine in a Bioequivalence Study,”
Pharmaceutical Research, Vol. 51, No. 5, 2005, pp. 445-
452. doi:10.1016/j.phrs.2004.11.006
[24] F. Franconi, S. Brunelleschi, L. Steardo, et al., “Gender
Differences in Drug Respo nses,” Pharmaceutical Resea rch,
Vol. 55, No. 2, 2007, pp. 81-95.
doi:10.1016/j.phrs.2006.11.001
[25] D. J. Greenblatt, M. Divoll and D. R. Abernethy, “Physi-
ologic Changes in Old Age: Relation to Altered Drug
Disposition,” Journal of the American Geriatrics Society,
Vol. 30, Supplement 11, 1982, pp. S6-S10.
[26] M. Chen, L. Ma, G. L. Drunsano and A. N. Nafziger,
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