P. RANDAZZO-MOURA ET AL.
118
ruption or interfering with body function, being generally
incompatible with life. Developmental variations are
defined as anatomical structure alterations having no
significant biological effect on health or body conformity,
usually representing slight deviations from normal 22.
Considering the offspring external morphological mea-
surements in the present study, Cg extract did not induce
significant effects in these measurements when com-
pared with the control group. Studies carried out to es-
tablish the potential ability of drugs to induce adverse
effects on the fetal development, which used acceptable
and rationale experimental design, could provide accu-
rate extrapolation of the potential risk in human beings of
that particular drug. Considering the previous study per-
formed by Gerenutti et al. 16, which used the same
aqueous extract of Cg, it was possible to conclude that
Cecropia glazioui Snethlage presents no toxicity on
morphological development of rat offspring.
5. Acknowledgements
This work was supported by UNISO. R-M, P. was stu-
dent of Scientific Initiation from UNISO.
6. References
[1] F. F. Rocha, A. J. Lapa and T. C. de Lima, “Evaluation of
the Anxiolytic-Like Effects of Cecropia glazioui Sneth in
Mice,” Pharmacology, Biochemistry and Behavior, Vol.
71, No. 1-2, 2002, pp. 183-190.
doi:10.1016/S0091-3057(01)00695-5
[2] F. F. Rocha, M. T. Lima-Landman, M. M. Tanae, T. C.
de Lima and A. J. Lapa, “Antidepressant-Like Effect of
Cecropia glazioui Sneth and Its Constituents―In Vivo
and in Vitro Characterization of the Underlying Mecha-
nism,” Phytomedicine, Vol. 14, No. 6, 2007, pp. 396-402.
doi:10.1016/j.phymed.2007.03.011
[3] S. Delarcina, M. T. Lima-Landman, C. Souccar, R. M.
Cysneiros, M. M. Tanae and A. J. Lapa, “Inhibition of
Histamine-Induced Bronchospasm in Guinea Pigs Treated
with Cecropia glaziovi Sneth and Correlation with the in
Vitro Activity in Tracheal Muscles,” Phytomedici ne, Vol.
14, No. 5, 2007, pp. 328-332.
doi:10.1016/j.phymed.2006.12.022
[4] M. T. Lima-Landman, A. C. Borges, R. M. Cysneiros, T.
C. de Lima, C. Souccar and A. J. Lapa, “Antihypertensive
Effect of a Standardized Aqueous Extract of Cecropia
glaziovii Sneth in Rats: An in Vivo Approach to the Hy-
potensive Mechanism,” Phytomedicine, Vol. 14, No. 5,
2007, pp. 314-320. doi:10.1016/j.phymed.2007.03.003
[5] M. F. Ninahuaman, C. Souccar, A. J. Lapa and M. T.
Lima-Landman, “ACE Activity during the Hypotension
Produced by Standardized Aqueous Extract of Cecropia
glaziovii Sneth: A Comparative Study to Captopril Ef-
fects in Rats,” Phytomedicine, Vol. 14, No. 5, 2007, pp.
321-327. doi:10.1016/j.phymed.2006.12.010
[6] C. Souccar, R. M. Cysneiros, M. M. Tanae, L. M. Torres,
M. T. Lima-Landman and A. J. Lapa, “Inhibition of Gas-
tric Acid Secretion by a Standardization Aqueous Extract
of Cecropia glaziovii Sneth and Underlying Mechanism,”
Phytomedicine, Vol. 15, No. 6-7, 2008, pp. 462-469.
doi:10.1016/j.phymed.2008.02.006
[7] R. Lewontin, “It Ain’t Necessarily So: The Dream of the
Human Genome and Other Illusions,” New York Review
Books, New York, 2000.
[8] M. Wink, “Physiology of Secondary Product Formation
in Plants,” In: B. V. Charwood and M. J. C. Rhodes, Eds.,
Secondary Products from Plant Tissue Culture, Claren-
don, Oxford, 1990, pp. 67-86.
[9] M. M. Tanae, M. T. Lima-Landman, T. C. de Lima, C.
Souccar and A. J. Lapa, “Chemical Standardization of the
Aqueous Extract of Cecropia glaziovii Sneth Endowed
with Antihypertensive, Brochodilator, Antiacid Secretion
and Antidepressant-Like Activities,” Phytomedicine , Vol.
14, No. 5, 2007, pp. 309-313.
doi:10.1016/j.phymed.2007.03.002
[10] Brasil, Ministério da Saúde, Agência Nacional de Vigi-
lância Sanitária, Resolução de Diretoria Colegiada 48,
Diário Oficial da União, Brasília, 2004.
[11] Brasil, Ministério da Saúde, Agência Nacional de Vigi-
lância Sanitária, Resolução 88, Diário Oficial da União,
Brasília, 2004.
[12] Brasil, Ministério da Saúde, Agência Nacional de Vigi-
lância Sanitária, Resolução 89, Diário Oficial da União,
Brasília, 2004.
[13] Brasil, Ministério da Saúde, Agência Nacional de Vigi-
lância Sanitária, Resolução 90, Diário Oficial da União,
Brasília, 2004.
[14] Brasil, Ministério da Saúde, Agência Nacional de Vigi-
lância Sanitária, Resolução 91, Diário Oficial da União,
Brasília, 2004.
[15] Brasil, Presidência da República, Decreto 5813, Diário
Oficial da União, Brasília, 2006.
[16] M. Gerenutti, A. F. Prestes, M. G. Silva, F. de S. Del Fiol,
Y. O. Franco, P. C. Venâncio and F. C. Groppo, “The
Effect of Cecropia glazioui Snethlage on the Physical and
Neurobehavioral Development of Rats,” Pharmazie, Vol.
63, No. 5, 2008, pp. 398-404.
[17] B. H. Vickery and J. P. Bennett, “Rats and Mice,” In: E.
S. E. Hafez, Ed., Reproduction and Breeding Techniques
for Laboratory Animals, Lea & Febiger, Philadelphia,
1970, pp. 299-315.
[18] K. A. Keller, “Developmental and Reproductive Toxi-
cology,” In: D. Jacobson-Kram and K. A. Keller, Eds.,
Toxicology Testing Handbook: Principles, Applications
and Data Interpretation, Marcel Dekker, Inc., New York,
2001, pp. 195-254.
[19] M. Gerenutti, A. H. de-Souza Spinosa and M. M. Ber-
nardi, “Effects of Bracken Fern (Pteridium aquilinum L.
Kuhn) Feeding during the Development of Female Rats
and Their Offspring,” Veterinary and Human Toxicology,
Vol. 34, No. 4, 1992, pp. 307-310.
[20] M. Gerenutti, F. Del Fiol and F. C. Groppo, “Reproduc-
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