International Journal of Organic Chemistry
Vol.04 No.05(2014), Article ID:52836,7 pages
10.4236/ijoc.2014.45036

The Research Progress of Hexafluorobutadiene Synthesis

Jing Zhu, Shuang Chen, Baohe Wang, Xiaorong Zhang

Research and Development Center of Petrochemical Technology, Tianjin University, Tianjin, China

Email: cj_zhu1975@tju.edu.cn

Copyright © 2014 by authors and Scientific Research Publishing Inc.

This work is licensed under the Creative Commons Attribution International License (CC BY).

http://creativecommons.org/licenses/by/4.0/

Received 21 October 2014; revised 3 December 2014; accepted 19 December 2014

ABSTRACT

Hexafluorobutadiene is a new plasma etching gas for semiconductor molectron which has perfect properties and also is a preceding monomer that can be used for synthesizing many fluorinated compounds. This paper described the different synthesis methods of perflurobutadiene from different materials, and contrasted the characteristic of each synthetic method. The route from tetrafluoroethylene has more industrialization prospects.

Keywords:

Perfluorobutadiene, Synthesis, Diiodoperfluoroalkanes, Trifluoromonochloroethylene, Tetrafluoroethylene, 1,2-Difluoro-1’,2’-dichloroethylene

1. Introduction

Hexafluorobutadiene, which is a fully fluorinated compound with double bonds, has the boiling point of 5.6˚C and the density of 1.4 g/ml (15˚C). It shows a good foreground as monomer in the synthesis process of fluoro- resins, fluoroplastics and fluororubbers. In addition, it can be copolymerized with other monomers to synthesis high performance fluoroelastomer and resins with excellent electric properties [1] - [3] . However, the present researches on hexafluorobutadiene application focus mainly on dry etching of VLSI, and studies suggest that it is a fine electrical etching gas with high selectivity and accuracy [4] - [7] . So far, only a few companies produce hexafluorobutadiene all over the world because of the difficulties in its preparation. The preparation methods of hexafluorobutadiene are introduced in this article in order to provide some ideas for the industrialized development.

2. Hexafluorobutadiene Application

2.1. Novel Cyanine Dye

Cyanine dye first appeared in 1856, and it is widely used in synthetic organic chemistry and physical chemistry due to its structural variability. Recently, researchers have found emerging applications of cyanine dye in solar energy utilization, for instance, Rensmo [8] indicated that nanocrystalline ZnO electrode, which was sensitized by organic dye, can be used as photo-anodes in photoelectrochemical solar cell, and photoelectric conversion efficiency of the photoelectrochemical solar cell was 2%. Yagupolskii [9] suggested that a fluorine atom introduced in the connecting bridge could effectively increase the absorbance range of the dye, and Yagupolskii [9] successfully introduced the flooring system into the cyanine dyes via reaction of perfluorobutadiene and benzothiazole, so that the maximum absorption wavelength of the dye was increased from 453 nm to 578 nm. The synthesis process is mainly divided into three steps: synthesized 2-perfluorobutadiene benzothiazole by the reaction of benzothiazole basic magnesium chloride and perfluorobutadiene in tetrahydrofuran solvent at −40˚C, and then, prepared N-methyl-2-perfluorobutadiene benzothiazoles boron tetrafluoride salt(I) by the alkylation reaction of 2-perfluorobutadiene benzothiazole with iodomethane under the catalysis of AgBF4. Lastly, the dehydrofluorination reaction of the salt(I) and N-methyl-2-fluorine methylene benzothiazole was conducted to get the cyanine dyes. The specific procedures were as follows (Scheme 1).

2.2. Plasma Atching Agent

Recently, many researches had focused on dry etching process of VLSI [10] using hexafluorobutadiene. In the manufacturing process of semiconductor devices, etching process is to use as chemical solvent, corrosive gas or plasma to remove unwanted parts in the wafer or wafer surface layer. Wet etching, which always happened in a chemical solution, conducted isotropic etching reaction under the action of strong acids and can also etch the covered parts. In contrast, dry etching with corrosive gas or plasma ion could realize anisotropic etching in vertical direction on the wafer. Thus, dry etching is applicable to high-precision fine craft, such as large scale integrated circuit (VLSI) etching process.

Hexafluorobutadiene, which is an environmental friendly laser etching gas and just appeared on the market in 2004, etches the line width of 90 nm or less [11] . Compared with octafluorocyclobutane (C4F8) which is widely used at present and etches the line width of 130 nm, hexafluorobutadiene has several distinguished features: 1) faster degradation speed in atmosphere. C4F6 can be degraded in two days while C4F8 requires 3200 years; 2) lower greenhouse effect. Greenhouse effect produced by C4F6 is only equivalent to 1/1,000,000 of carbon dioxide and 1/870,000 of octafluorocyclobutane; 3) higher aspect ratio. Hexafluorobutadiene is suitable for the extremely narrow line width process, and its aspect ratio can be up to 10 while the aspect ratio of octafluorocyclobutane is only 3; 4) higher selectivity. It only etches silicon oxide membrane without affecting the photoresist, silicon membrane or nitride membrane. Hexafluorobutadiene (C4F6) is 4.5 times the selectivity of carbon tetrafluoride (CF4), while octafluorocyclobutane (C4F8) is 4 times the selectivity of carbon tetrafluoride (CF4).

Recently, there are several companies focus on the research and development of hexafluorobutadiene, such as Ausimont of Italy, Kanto electrification of Japan, Asahi Glass, Dakin, Russia NITs Medkhim, United States PCBU SERVICES INC. However, only Ausimont and Kanto electrification have the capacity of tons productive scale. With the increasing demand of very large scale integrated circuit and the attention to greenhouse gases, it

Scheme 1.The synthesis process of the flooring system into the cyanine dyes via reaction of perfluorobutadiene and benzothiazole.

is foreseeable that hexafluorobutadiene, which has the characteristics of the best etching effect and environmental friendly, will become the leading product and will be widely used in the laser etching agent market.

3. The Synthesis of Hexafluorobutadiene

3.1. Using 1,2-Difluoro-Dichloroethylene (CFCl=CFCl) as Raw Material

In 1956, Ruh [12] firstly prepared hexafluorobutadiene using 1,2-difluoro-dichloroethylene as raw materials. The autoclave was charged with 1,2-difluoro-dichloroethylene, and then heated to 275˚C. The reaction was con- ducted in presence of mercury salts catalyst for 6 h, then the reaction mixture was distilled to obtain 1,3,4,4-te- trafluorotetrachloro-1-butene, and the yield was 87.4% (mol). Thereafter, addition reaction between the above product and chlorine was conducted in presence of photocatalyst to get 1,1,2,3,4,4-hexachloro-tetrafluorobutane, and the yield was 99.4%. After that the 1,1,2,3,4,4-hexachloro-tetrafluorobutane and SbF3Cl2 were added to the autoclave and stirred at 250˚C for 5 h, then1,2,3,4-tetrachloro-hexafluorobutane was generated and the yield was 89.6%. At last, 1,2,3,4-tetrachloro-hexafluorobutane was dissolved in anhydrous ethanol in a glass bottle with zinc powder to act dechlorination reaction. Hexafluorobutadiene was obtained and the yield was 93.5%. The specific reaction equations were as follows:

William T. Miller [13] reacted 1,2-difluoro-dichloroethylene with fluorine under 0.9 to 1.0 MPa at room temperature for 26 h, then1,2,3,4-tetrachloro-hexafluorobutane was obtained directly and the yield was about 51% (mol). Thereafter, the above product and zinc powder were mixed in the diethylene glycol monobutyl ether, and the 1,2,3,4-tetrachloro-hexafluorobutane was dechlorinated directly to prduce hexafluorobutadiene. The equation was as follows:

Since this method has the disadvantages of harsh reaction conditions, lower yield and poisonous and highly corrosive materials, there is no application of this method in industry yet.

3.2. With Chlorotrifluoroethylene (CF2=CFCl) as Raw Material

In 1957, Haszeldine [14] prepared hexafluorobutadiene using chlorotrifluoroethylene as raw material. The reaction firstly proceeded at 35˚C to 40˚C to give 1,2-dichloro-1,2,2-trifluoro-1-iodoethane and 2,2-dichloro-1,1, 2-trifluoro-1-iodoethane, and the yield was 97%. Then 1,2-dichloro-1,2,2-trifluoro-1-iodoethane was purified and mixed with the same amount of mercury. Under UV irradiation for 48h, 1,2,3,4-tetrachloro-hexafluorobu- tane was obtained, and the yield was 95%. After that, hexafluorobutadiene was got through the dechlorination reaction between the above product and zinc powder in ethanol solution, the yield was 98%. The detailed reaction equations were as follows:

William. T. Miller [13] decomposed trifluorochloroethylene in Pyrex tube under normal pressure at 550˚C to generate l,2-dichloro-hexafluorocyclobutane and 3,4-dichloro-hexafluoro-1-butene,the conversion was about 36.2%. Because of having similar boiling point, the above products were directly added into a glass tube without separation to react with liquid chlorine. Under the light of 200 w at room temperature for 24 h, 3,4-dichloro- hexafluoro-1-butene converted to 1,2,3,4-tetrachloro-perfluorobutane with the yield of 15.16% (mol). The reaction products was separated to obtain 1,2,3,4-tetrachloro-hexafluorobutane and l,2-dichloro-hexafluorocyclobu- tane. Finally, 1,2,3,4-tetrachlorohexafluorobutane was dechlorinated using zinc powder in ethanol to get hexafluorobutadiene. The reaction process was as follows:

The generated 1,2-dichlorohexafluorocyclobutane is dehydrogenized using zinc powder in ethanol to get hexafluorocyclobutene [15] . D. Young [16] investigated the reaction of 1,2,3,4-tetrahydro-perfluorobutane and hydrogen at 250˚C - 300˚C for 21.5 h under the pressure of 280 psig in the presence of iodine catalyst, and the yield of product 1,2,3,4-tetrahydroperfluorobutane was more than 90%. Thereafter, the product was distillated under reduced pressure and added into Vycor tube which contained a small amount of H2O and excessive chlorine, after irradiation of 100 w tungsten filament lamp for 85 h, 1,2,3,4-tetrachloridehexafluorobutane and a handful of impurities were obtained. The 1,2,3,4-tetrachloridehexafluorobutane was separated from the mixtures after washing with alkaline, and then dechlorinated with zinc powder in ethanol. The reaction equations were as follows:

Veeraraghavan [17] developed a one-step synthetic method of hexafluorobutadiene using chlorotrifluoroethylene as raw materials. In the presence of various salt catalysts, reactions of trifluorochloroethylene and trifluorobromoethylene were studied. Reactions using copper salts catalyst and iron salts catalyst were preferable. Specific steps were presented as follows: Three necks’ bottle was charged with zinc powder and anhydrous DMF, after cooling of dry ice, trifluorobromoethylenee was added slowly. Then, reaction system was heated up to 70˚C, and trifluoroethene zinc-bromine was formed after 1 h. Under the condition of 0˚C - 5˚C, 100 mmHg vacuum and high purity nitrogen flow, displacement reaction was conducted by slowly adding iron salt (FeCl3 or FeBr3) or copper salt (Cu (OTf)2 or Cu (OAc) 2). The generated gas was collected by a refrigerant of −78˚C. Lastly, reaction system was heated up to 40˚C and keep stirring for 2 h in order to discharge all the produced gas. The total yield was between 62% and 70%. Specific process was as follows:

Robertovich [18] synthesized perfluorobutadiene in the presence of PdCl2 (PhCN)2 and three p-phenyl phosphine p(o-CH3C6H5) as catalyst at 50˚C - 60˚C by trifluorochloroethylene directly dechlorination with excessive zinc powder, and the maximum yield was 34%.

Wang Yi [19] add the 1,1,2-tribromo-trifluoroethane which was synthesized by bromo-trifluoroethylene and bromine slowly into the mixture of excessive zinc powder and DMF at 50˚C - 70˚C, then the mixtures was heated up to 80˚C - 90˚C, and maintained for 1h. After the mixture was cooled to 0˚C - 5˚C, a solution of ferric trichloride and DMF was added. The generated hexafluorobutadiene is cooled at −25˚C, with total yield of 42.12%.

In the above synthetic routes, many serious environmental pollutions exist due to the using of poisonous and harmful materials during the dehalogenation and coupling reactions of 1,2-dichloro-1,2,2-trifluoro-1-ethyl iodide, such as acetic anhydride and iodine chloride. In addition, utilization rate is low. Meanwhile, dechlorination reac- tion products at the last step contain a lot of unreactive chlorine compounds, which brought greater difficulty to subsequent purification. However, this synthesis route is one of the earlier developed and mature route and the raw materials is cheap, so that some companies in Russia and Japan established tons scale industrial production devices using this method to product hexafluorobutadiene. Although the one-step method had the advantages of simple operation and wide raw material sources, the condition was rigorous and not easy to control. So far it is confined to the laboratory synthesis, but it has a good industrialization prospect if several key problems will be solved.

3.3. With Trichloroethylene as Raw Material

Vito Tortelli et al. [20] synthesized C4H2F2Cl6 by reacting trichloroethylene (TCE) and fluorine diluted with 10 times helium in autoclave until mole ratio of TCE and fluorine was 6.6:1, the flow rate of fluorine was 1 Nl/h, the conversion rate of TCE is 24% and selectivity of C4H2F2Cl6 is 60%. Under the condition of reaction temperature less than 35˚C, the reaction of C4H2F2Cl6 and 20% NaOH solution was catalyzed with methyltrioctylammonium chloride by strongly stirring for 8h to obtain 1,2,3,4-tetrachloro-difluoro-butadiene, and the yield was 93%. Then the mixture of the above product, fluorine and helium were added in 50 ml autoclave which was charged of 50.1 gram CF3OCFClCF2Cl, the flow rates of 1,2,3,4-tetrachloro-difluoro-butadiene, fluorine and helium were 9.4 g/h, 9.4 Nl/h and 0.75 Nl/h respectively. The reaction proceed at 10˚C for 1 h, the conversion of 1,2,3,4-tetrachloro-difluoro-butadiene was 97.8%, and selectivity of 1,2,3,4-tetrachloro-perfluorobutane (CFC316) was 64%. At last, hexafluorobutadiene was formed by reaction of 1,2,3,4-tetrachloro-perfluorobutane with zinc powder in 2-propanol, the yield was 95%, while overall yield in the process of TCE was 33.92%. Specific process was as follows:

3.4. With Tetrafluoroethylene (CF2=CF2) as Raw Materials

The route of using tetrafluoroethylene as main raw material is divided into two steps: the first step is that tetrafluoroethylene react with iodine or bromine to generate 1,2-dihalo -tetrafluoroethane, and then telomeric reaction between 1,2-dihalo-tetrafluoroethane and tetrafluoroethylene is conducted under certain temperature and pressure to produce a series of α, ω-dihalo-perfluoroalkanes; The second step is that the separated 1,4-dihalo-octaf- luorobutane dehalogenate to generate hexafluorobutadiene.

3.4.1. Synthesis of 1, 4-Dihaloperfluorobutane

The earliest report of synthesis of diiodoperfluoroalkanes was by Haszeldine in 1951 [21] and after that, large research efforts had been focused on this issue because of the increasing industrial demand. Dindi Hasan and Hagedorn [22] used tetrafluoroethylene and 1,2-diiodotetrafluoroethane to produce diiodoperfluoroalkanes, the total conversion of 1,2-diiodotetrafluoroethane reached 96% after 12 - 20 hours reaction under 245˚C and 3.65 - 3.86 Mpa. Catalysis telomerization reaction was also developed [23] , using benzoyl peroxide as catalyst; after 26 hours reaction under 80˚C, 650 psig, the mixture of I(C2F4)nI (n = 1, 2, 3, 4)was acquired. Zhang Zongli [24] using Cu as catalyst, synthesized diiodoperfluoroalkanes by telomerization method with tetrafluoroethylene and 1,2-diiodotetrafluoroethane; after 4 hours under 260˚C, the conversion reached 57%, the selectivity reached 75%. V. Tortelli and C. Tonelli [25] has developed a one step route in which tetrafluoroethylene and iodine was used to synthesize 1,2-diiodotetrafluoroethane at first, then 1,2-diiodotetrafluoroethane continued to react with superfluous tetrafluoroethylene. Suzuki Kaichirou [26] synthesized diiodoperfluoroalkanes by thermal deiodination reaction of 1,2-diiodotetrafluoroethane under 250˚C, the conversion of 1,2-diiodotetrafluoroethane was 70%. Overall, thermal deiodination reaction and telomerization are currently the prevailing methods to synthesize DIPFAs. However, both methods need 1,2-diiodotetrafluoroethane as raw material.

Thermal pyrolysis:

Telomerization:

3.4.2. Synthesis of Hexafluorobutadiene

1,4-diiodooctafluorobutane separated from homologue of diiodoperfluoroalkanes could be transformed into hexafluorobutadiene by the two methods: one is that 1,4-diiodooctafluorobutane and a certain metal like Zn or Mg deiodinate in protic solvent to produce hexafluorobutadiene; The other is that 1,4-diiodooctafluorobutane react with Grignard reagent in aprotic solvents to get hexafluorobutadiene.

MIKI, Jun and YOSHIMI [27] synthesized hexafluorobutadiene by reacting I-CF2-CF2-CF2-CF2-I and zinc powder in DMF, the process was as follow: I-CF2-CF2-CF2-CF2-I was mixed with zinc powder , slowly heated to 120˚C for 30 minutes, a mixture of DMF and Zn was droped into the reactants, and the reaction was kept moderate. Then gas mixture containg hexafluorobutadiene was obtained after 30 minutes, the content of hexafluorobutadiene was 65%, and the yield was 53.66%. In contrast, when perfluorochemical (such as FC-30) was added into the reaction as solvent and reaction proceed under 140˚C, the content of hexafluorobutadiene in the mixed gases is 88%, and the overall yield of the process is 64.74%. Reaction equations were as follows:

The above reaction has advantages of simple process and available raw materials, but once it was triggered, the reaction would appear some phenomena, such as releasing a large amount of heat, reacting violently, controlling difficultly, and producing a plenty of by-products, furthermore, the total yield of the products is relatively low. So far, it hasn’t been found for industrialization.

Gianangelo synthesized hexafluorobutadiene in the following ways. At first, 1,4-diiodooctafluorobutane [28] or 1,4-dibromooctafluorobutane [29] and tetrahydrofuran (THF) were mixed, heated to boil, and Grignard reagent made from bromoethane and Mg with a concentration of 1 mole was slowly added, the reaction was controlled moderately. The generated gas was only hexafluorobutadiene, the yield was 71.6%. By analysis, the solution still contained a small amount of hexafluorobutadiene, the overall yield was 96%.

Hae-Seok Ji, et al. [30] reported that magnesium powder and a little of Grignard reagent with concentration of 1 mole were added into 1 litre toluene, the mole rate of magnesium powder to 1,4-diiodoperfluorobutane is 1.5:1, under strongly stirring, the mixture was heated to boil, and then slowly droped 400 grams of 1,4-dibro-moper- fluorobutane in 3 hours, thereafter, product was collected using cold media with a temperature of −40˚C. The weight of product was 178 grams. The content of hexafluorobutadiene was 96%. The yield of hexafluorobutadiene was 94.93%. Reaction equations were as follows:

Comparing to the dehalogenation reactions using metals, the reaction using Grignard reagent to get hexafluorobutadiene has the obvious advantages: moderate reaction conditions, low impurity content, relatively high yield and selectivity. However, products in the reaction using Grignard reagent contain the isomer of perfluorocyclobutane, whose boiling point is only higher 0.8˚C than perfluorobutadinene, so that the products are purified with more difficultly. At the same time, using Grignard reagent as raw material had an extremely harsh using condition, that’s to say it should be prepared at service times. It increased the difficulty of realizing industrial production to a certain extent, thus, the method hasn’t been found in the industrial production. Although these synthesis methods had quite a few shortcomings, α, ω-diiodoperfluoroalkanes, which was an intermediate for many synthesis of useful fluorinated compound, was used extensively, in addition, it could obviously reduce the production cost of hexafluorobutadiene and made this method have extremely strong competitiveness.

3.4.3. With Waste PTF as Raw Materials

Considering the severe reaction conditions and using of the high purity tetrafluoroethylene monomer, a new synthesis method of 1,2-diiodotetrafluoroethane has been developed. The detail process is as follows: firstly, waste tetrafluoroethylene was pyrolyzed to obtain tetrafluoroethylene monomer at 500˚C and 2 kPa [31] . The conversion of waste tetrafluoroethylene pyrolysis reaction was 99.6%, and the yield of tetrafluoroethylene monomer was 95.52%. And then the pyrolysis gas, which also contained hexafluoropropylene and octafluorocyclobutane, directly reacted with iodine at 150˚C and 1.2 MPa without separation, and the conversion of iodine was 98.05%, while the selectivity was 98.4%. In terms of the conversion and selectivity of iodine, there was no essentially difference between the two means of using pyrolysis gas and high purity tetrafluoroethylene as raw material respectively.

Based on the above green synthesis process, a further study on the one-step synthesis method of α, ω-diiodo- perfluoroalkanes [24] has been also developed. Preparation of 1,2-diiodotetrafluoroethane and synthesis of 1,4- diiodooctafluorobutane were conducted by one step reaction, which not only reduced the loss of materials, but also greatly shortened the reaction time and improved the yield of target product. Detail process is as follows: the autoclave was charged with iodine, solid copper powder and 1,2-diiodotetrafluoroethane as solvent, and then heated to 160˚C to synthesize 1,2-diiodotetrafluoroethane. After iodine reacted completely by inletting into pyrolysis gas, C2F4 was continuously fed to keep a certain pressure in the autoclave, and then the reaction proceed for 4 hours at 260˚C. After that the reaction temperature was reduced to 160˚C and C2F4 gas was continuously added to react with elemental iodine generated during thermal pyrolysis reaction. 1,2-diiodotetrafluoroethane in the product was separated by distillation to recycle as solvent. According to I(C2F4)I, the total mole yield of 1,4-diiodooctafluorobutane was 68.15%.

1,4-diiodooctafluorobutane, which was obtained by distillating from the above reaction product, reacted with the Grignard reagent to get hexafluorobutadiene through reactive-distillation process [32] . Specific reaction process was as follows: 400 ml tetrahydrofuran was placed into the tower kettle with a thermocouple, Grignard reagent and tetrahydrofuran solution contained diiodooctafluorobutane were respectively added in the two dropping funnel, Grignard reagent was prepared with bromobenzene and Mg in the diethyl ether, and the addtion amount of Grignard reagent and tetrahydrofuran solution were 670 ml (2.01 mol) and 454 g (1.0 mol) respectively. Under the protection of nitrogen with a flow rate of 0.5l/h, tetrahydrofuran was heated to boil, the cooling temperature of tower top was maintained between 6˚C - 7˚C, and a certain return flow on the top of the tower was kept. After total reflux, Grignard reagent and diiodooctafluorobutane solution were droped slowly from the middle of distillation tower during 3 - 4 h, and the mass of 164 g of crude product hexafluorobutadiene was got by collecting with a low temperature of −90˚C in cold trap. The conversion rate of 1,4-diiodooctafluorobutane was 99.53%, the yield of hexafluorobutadiene was 96.75%, and the selectivity was 97.2%.

4. Conclusion

Hexafluorobutadiene (C4F6) is a new plasma etching agent which is used in the manufacture process of the large scale integrated circuit and memory chips with high speed and high capacity. It is also a synthetic monomer of many materials, such as a new type of fluorine resin, fluorine plastic and fluorine rubber. However, only Italy and Japan have the capacity of more than ton scale production of hexafluorobutadiene, which makes its market price high ($500 - $600/kg) at present. So it has extremely good economic prospect to develop industrial production approach of hexafluorobutadiene as soon as possible. Among these several synthetic methods of hexafluorobutadiene, the synthetic method using trifluorochloroethylene as material is mainly route being used in industrial manufacture. This route has advantages of mature technology, raw material easy to get and simple operation, but the chlorine compound generating in the reaction and raw material trifluorochloroethylene all destroys the Ozone layer, and is prohibited to use in many countries. The strict requirement to the content of chlorine compound in hexafluorobutadiene makes the refinement of production become more difficult and the cost of production becomes higher. In the contrast, the route using tetrafluoroethylene as raw material has a lower costing of production because the 1,6-diiodoperfluorohexane and 1,8-diiodoperfluorooctane by-products also have a high price. Furthermore, the intermediates are iodine compounds, so that this route has none environmental problems. Now, the waste polytetrafluoroethylene using as raw material can further reduce the costing of hexafluorobutadiene production. If the restrictions of Grignard reagent application can be reduce, the route will have very good prospects for industrial application.

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