Advances in Biological Chemistry, 2013, 3, 553-555 ABC Published Online December 2013 (
Pre-Chelates, Post-Adducts and Implexes: A perspective
proposal for the future of medicinal chemistry
Mario Gosalvez*
Laboratory and Service of Experimental Biochemistry, Clínica and Hospital Universitario Puerta de Hierro, Madrid and
Majadahonda, Comunidad de Madrid, Spain
Received 18 September 2013; revised 25 October 2013; accepted 12 November 2013
Copyright © 2013 Mario Gosalvez. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The title of this little assay coins three new words:
Pre-Chelates, Post-Adducts and Implexes. These, very
daring new excursions into the scientific English lan-
guage, come from the developments of Quelamycin
and Sodium L-Thioproline, through our different
group studies arriving to cancer reversal by a dual
strategy. It is enough to read all our published mate-
rials, cites and related papers, dealing more or less
with the chemistry and possible mechanism of action
of these compounds, to gather somewhat what signi-
fied our monomeric-triferric-doxorubicine, as possi-
bly one of the first Pre-Chelates and our Sodium
L-Thioproline, probably as one of the first Post-Ad-
ducts. Both molecules come to the human patients
with cancer blood from the exterior. After this indica-
tion, it will be proposed a seed concept of a new type
of molecules, the “Implexes” in which the metals will
be embraced instead of being linked.
Keywords: New Chelates and Adducts; Embracing
Metals, Future of Medicinal Therapeutics; Quelamycin;
In a series of recently published mini-reviews in open
journals, we have cited the more important references in
our contributions to Quelamycin and Thioproline and its
possible utility for cancer reversal by dual strategy and
cancer as a therapeutic agent [1-4]. It is enough to read
these texts, their therein cites and its related papers to be
well aware of what these new molecules would represent
as one of the first Pre-Chelates and Post-Adduct, respec-
Let me please finish, for the moment, these two possi-
ble chapters of the future medicinal chemistry by saying
that the different Pre-Chelates and Post-Adducts, of im-
portant molecules of the past, among perhaps our con-
tributions on Quelamycin and Thioproline are p ioneering
efforts [1-4]. At present, and in the future, it could be
more or less evolved aiming to further real advances of the
curative medicine and surgery of the times to come.
Thus, having left already these two balls in the fields
of biological chemistry experts, I will dedicate this very
short article mainly to the Proposal Perspective of “Im-
plexes”. A word that, I coined decades ago as a concept
not yet considered by biological chemistry. It would be
very crucial that the more attentive scrutiny of my fol-
lowing stuttering discourse will come from those more
projective experts in advanced chemistry. Their ages are
not important.
I am truly just a medical doctor with some scientific
experience, who is always trying to help the suffering
patient of any disease looking for definitive cures.
I certainly think that, to really attempt to convey to
chemical biology experts, with enough clarity and sim-
plicity, wh at could represent with decades ahead of work
a new step forward in curative physiological pharmacol-
ogy, I would need, if you permit me please, some phi-
losophy of chemistry. That is to say to search for the
deeper concep ts that lie in the h umanity wanting to know
of what all is made at the end. These sciences have ar-
rived nowadays, on one hand, at the subatomic chemistry
that so far has resulted in atomic particles physics and
mathematical diverse plays with the intangible. On the
other hand, the molecular neuropharmacology has ar-
rived to psychotropic chemical molecules with several
effects on human emotional and mental traits.
Without needing to resort to its origins in Alchemy,
*Former Head. (1970-2010)
M. Gosalvez et al. / Advances in Biological Chemistry 3 (2013) 553-555
chemistry searched first to define the inner composition
of samples of inert matter most calling the attention of
human society. Latter arrived to define the chemical
structure of organic compounds of importance for life.
Urea, Penicillin and Insu lin name three of the early great
efforts. These are some among the first milestones of
chemical synthesis together with Chlorophyll.
With the progressive development of biochemistry, in
the last century, the chemistry of life has started to show
the immense variety of molecular compositions with
higher sense, utility and possibly finality. In some case
the simplicity of the solution by nature of the utmost
complex task had some biochemists saying to the chem-
Do you think that such enormous beauty of molecule
would have been arrived at, just by chance, necessity and
of natural blind evolution?
In the next decades of the 21st siècle chemical sci-
ences could reach however the right molecules to control
definitively diseases without secondary toxicities by
chemicals so far of impossible synthesis in the laboratory.
Of course, first in humans and after in those animals and
vegetables more related to our society. I think that the
Earth could arrive in few centuries to collaborate with
the unicellular beings of phytoplankton and zooplankton.
These are the massive and important components of life
in our planet for the permanence of life and humanity at
I think that the better conditions for chemical synthesis
invented by Nature are shown by the living cells and
organisms. There are many thousands different type of
cells for different tasks, either as single organisms, cel-
lular aggregates or forming the tissues of a more com-
plex living beings. For impossible chemical synthesis for
our present technology I propose to copy as properly as
possible the living cells conditions for synthesis of
chemical biological molecules.
What are essentially these conditions?
They are very varied. Life can perform chemical syn-
thesis of complex molecules from very low to very high
temperatures. In the complete darkness or with the con-
course of light. In very varied atmospheric gas conditions,
nutrient´s availability, as it is adequate for survival and
adaptability including incredible levels of salinity or
methane concentration.
My group studied, decades ago, an assortment of
complex chemical compounds in its inhibitory effect in
rodent mitochondria, extracted and purified from plants
of the Canary Islands [5,6]. Many of these chemical
structures caused a complete reverence for Mother Na-
ture capacities for chemical synthesis in plants, even to
experts in natural compounds.
One of the important things to mention is that the liv-
ing cell interior’s constitute a “soup very heavy”. Even
water concentration, that is the more abundant simple
component of the living cell, rounds 55 Molar in the liver
rodent cells. Therefore as the pressure of ambient com-
pounds in this interior is very variegated the competing
enzymes must be very specific. The succession of pre-
cursor molecules of the compound aimed must be spe-
cifically tailored for the final task. The due thinking of
this concept needs a careful joinin g of the more co mplete
experience in biological and organic chemical synthesis.
I would suggest to try chemical synthesis in very thick
mesophases, changing amply the pressure, magnetic field,
temperature variations, ambient compounds, gases and
enzymes as need for the tasks programmed. The enzymes
first should be of vegetables or from unicellular beings,
those already known and perhaps the majority to be
searched in the next decades. Many other things could I
tell if counting with an appropriate collaboration in a
international economical effort to copy, doing things first
very artificially, life’s incredible simplest molecules with
great benefit for the future curative pharmacology of all
of us together better health
Instead of linking a metal with adequate chemical che-
lating forceps, please try to embrace it, and leave it freely
in its “Molecular Nest”. With it being capable of course
to react by, let us say, at this early step of my stuttering
thinking: Chemical Resonance.
To say, any word more in this step will compromise
the presentation of a generic patent by the main Indus-
tries possibly interested in this new research adventure.
This is not a journal to use cryptic chemical quantum
physics notions to disguise things to experts somewhat
lesser advanced in chemistry. Let however end with a
tender blink of my left eye:
“Chemical pertaining does not necessarily require
chemical bonds and can lead to a set forming part of one
set, or two sets, or more sets. It seems a contradiction but
perhaps these are situations very common in Life’s As-
tonishing Perfections” in my regard.
[1] Gosalvez, M. (2013) Reversal of cancer by dual strategy?
Journal of Cancer Therapy, 4, 518-520.
Copyright © 2013 SciRes. OPEN ACCESS
M. Gosalvez et al. / Advances in Biological Chemistry 3 (2013) 553-555
Copyright © 2013 SciRes. OPEN ACCESS
[2] Gosalvez, M. (2013) Metabolic control of respiration and
glycolysis of tumoral cells. Advances in Biological Che-
mistry, 3, 86-89.
[3] Gosalvez, M. (2013) Cancer as a therapeutic agent? Jour-
nal of Cancer Therapy. In press.
[4] Gosalvez, M. (2013) Methods to be developed for some
first applications of mitochondrial filamentation. Open
Journal of Biophysics, 3, 51-53.
[5] Gosalvez, M., et al. (1976) A screening for selective anti-
cancer agents among plant respiratory inhibitors. Euro-
pean Journal of Cancer, 12, 1003-1009.
[6] Gosalvez, M., et al. (1976) Effects and specificity of
anticancer agents on the respiration and energy metabo-
lism of tumor cells. Cancer Treatment Reports, 60, 1-7.