Preparation of Temperature and Water Responsive Microcapsules
Containing Hydroquinone with Spray Drying Method
Open Access JCDSA
54
20˚C are larger than those at 40˚C in the range of MC
concentration from CMC = 0 to CMC = 1.0 wt% because of
repression of swelling of microcapsules and diffusion of
water molecular due to PNIPAM.
However, at CMC = 1.5 wt%, the initial release velocity
at 40˚C is larger than that at 20˚C because of increase in
swelling and dissolution of MC as stated above.
On the other hand, the initial release velocities at 20˚C
are larger than those at 40˚C in the case of CMC = 0 and
MC25.
However, the initial release velocity at 40˚C is larger
than that at 20˚C in the case of MC400 and the initial
release velocities at 20˚C and 40˚C are almost the same
in the case of MC1500, because the solubility of MC is
decreased with molecular weight.
4. Conclusions
The microcapsules containing hydroquinone as the core
material, which were composed of ethyl cellulose,
methyl cellulose and P-N-isopropylacrylamid as the shell
materials, were prepared with the spray drying method.
The following results were obtained.
Microcapsules were responsive to temperature due to
P-N-isopropylacrylamid and water due to methyl cel-
lulose.
The released rate of HQ at 40˚C was smaller than that
at 20˚C because of repression of swelling of micro-
capsules and diffusion of water molecule due to hy-
drophobic P-N-isopropylacrylamid.
At the larger concentration of methyl cellulose, re-
sponsibility to water due to methyl cellulose was su-
perior to that to temperature due to P-N-isopropy-
lacrylamid.
Responsibility to water due to methyl cellulose was
decreased with molecular weight of methyl cellulose.
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