D. Rodin et al. / Open Journal of Animal Sciences 3 (2013) 49-5 2
Copyright © 2013 SciRes.
52
stability and DNA repair processes as well as tissue de-
velopment. There are many evidences showing that APP
is overexpressed in different cancer types [19,20]. Ge-
nomic destabilization and tissue development defects
resulted from APP overexpression can lead to morpho-
logical abnormalities in observed in transgenic flies.
OPEN A CCESS
5. ACKNOWLEDGEMENTS
The project is supported by the Russian Foundation for Basic
Research (grant No. 12-04-00898). The authors sincerely thank R.
Reifegerste for providing BACE Drosophila line.
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