N. Dil, A. G. Banerjee / American Journal of Molecular Biology 3 (2013) 248-254 253
University of Manitoba for technical assistance. This project was sup-
ported by research grants form Manitoba Health Research Council and
Manitoba Medical Service Foundation and by funds from Department
of Oral Biology and Faculty of Dentistry, University of Manitoba.
REFERENCES
[1] Jemal, A., Siegel, R., Ward, E., Hao, Y.P., Xu J.Q., Mur-
ray, T. and Thun, M.J. (2008) Cancer statistics, 2008. CA:
A Cancer Journal for Clinicians, 58, 71-96.
http://dx.doi.org/10.3322/CA.2007.0010
[2] Jemal, A., Center, M.M., Ward, E. and Thun, M.J. (2009)
Cancer occurrence. Methods in Molecular Biology, 471,
3-29. http://dx.doi.org/10.1007/978-1-59745-416-2_1
[3] Parkin, D.M., Bray, F., Ferlay, J. and Pisani, P. (2005)
Global cancer statistics, 2002. CA: A Cancer Journal for
Clinicians, 55, 74-108.
http://dx.doi.org/10.3322/canjclin.55.2.74
[4] Dobrossy, L. (2005) Epidemiology of head and neck
cancer: Magnitude of the problem. Cancer and Metasta-
sis Reviews, 24, 9-17.
http://dx.doi.org/10.1007/s10555-005-5044-4
[5] Ramqvist, T. and Dalianis, T. (2010) Oropharyngeal can-
cer epidemic and human papillomavirus. Emerging Infec-
tious Diseases, 16, 1671-1677.
http://dx.doi.org/10.3201/eid1611.100452
[6] Medzhitov, R., Preston-Hurlburt, P. and Janeway, Jr. C.A.
(1997) A human homologue of the Drosophila Toll pro-
tein signals activation of adaptive immunity. Nature, 388,
394-397. http://dx.doi.org/10.1038/41131
[7] Takeda, K., Kaisho, T. and Akira, S. (2003) Toll-like re-
ceptors. Annual Review of Immunology, 21, 335-376.
http://dx.doi.org/10.1146/annurev.immunol.21.120601.14
1126
[8] Akira, S., Uematsu, S. and Takeuchi, O. (2006) Pathogen
recognition and innate immunity. Cell, 124, 783-801.
http://dx.doi.org/10.1016/j.cell.2006.02.015
[9] Furrie, E., et al. (2005) Toll-like receptors-2, -3 and -4
expression patterns on human colon and their regulation
by mucosal-associated bacteria. Immunology, 115, 565-
574. http://dx.doi.org/10.1111/j.1365-2567.2005.02200.x
[10] Kelly, M.G., et al. (2006) TLR-4 signaling promotes
tumor growth and paclitaxel chemoresistance in ovarian
cancer. Cancer Research, 66, 3859-3868.
http://dx.doi.org/10.1158/0008-5472.CAN-05-3948
[11] Lee, J.W., et al. (2007) Increased toll-like receptor 9 ex-
pression in cervical neoplasia. Molecular Carcinogenesis,
46, 941-947. http://dx.doi.org/10.1002/mc.20325
[12] Park, J.H., et al. (2011) Toll-like receptor 5 activation
promotes migration and invasion of salivary gland ade-
nocarcinoma. Journal of Oral Pathology & Medicine, 40,
187-193.
http://dx.doi.org/10.1111/j.1600-0714.2010.00929.x
[13] He, W., et al. (2007) TLR4 signaling promotes immune
escape of human lung cancer cells by inducing immuno-
suppressive cytokines and apoptosis resistance. Molecu-
lar Immunology, 44, 2850-2859.
http://dx.doi.org/10.1016/j.molimm.2007.01.022
[14] Droemann, D., et al. (2005) Human lung cancer cells ex-
press functionally active Toll-like receptor 9. Respiratory
Research, 6, 1. http://dx.doi.org/10.1186/1465-9921-6-1
[15] Koch, A.E., et al. (1992) Interleukin-8 as a macro-
phage-derived mediator of angiogenesis. Science, 258,
1798-801. http://dx.doi.org/10.1126/science.1281554
[16] Strieter, R.M., et al. (1995) Role of C-X-C chemokines as
regulators of angiogenesis in lung cancer. Journal of
Leukocyte Biology, 57, 752-762.
[17] Murdoch, C., et al. (1999) Cxc chemokine receptor ex-
pression on human endothelial cells. Cytokine, 11,
704-712. http://dx.doi.org/10.1006/cyto.1998.0465
[18] Dil, N. and Banerjee, A.G. (2011) A role for aberrantly
expressed nuclear localized decorin in migration and in-
vasion of dysplastic and malignant oral epithelial cells.
Head & Neck Oncology, 3, 44.
http://dx.doi.org/10.1186/1758-3284-3-44
[19] Lalla, R.V., et al. (2001) Fibrin induces IL-8 expression
from human oral squamous cell carcinoma cells. Oral
Oncology, 37, 234-242.
http://dx.doi.org/10.1016/S1368-8375(00)00090-7
[20] Dil, N.and Banerjee, A.G. (2012) Knockdown of aber-
rantly expressed nuclear localized decorin attenuates tu-
mour angiogenesis related mediators in oral cancer pro-
gression model in vitro. Head & Neck Oncology, 4, 11.
http://dx.doi.org/10.1186/1758-3284-4-11
[21] Banerjee, A.G., et al. (2003) Aberrant expression and
localization of decorin in human oral dysplasia and squa-
mous cell carcinoma. Cancer Research, 63, 7769-7776.
[22] Hu, L., et al. (1991) Abnormal expression of retinoic acid
receptors and keratin 19 by human oral and epidermal
squamous cell carcinoma cell lines. Cancer Research, 51,
3972-3981.
[23] Hsu, S. et al. (2002) Transforming growth factor beta 1
dysregulation in a human oral carcinoma tumour progres-
sion model. Cell Proliferation, 35, 183-192.
http://dx.doi.org/10.1046/j.1365-2184.2002.00237.x
[24] Yu, L. and Chen, S. (2008) Toll-like receptors expressed
in tumor cells: Targets for therapy. Cancer Immunology,
Immunotherapy, 57, 1271-1278.
http://dx.doi.org/10.1007/s00262-008-0459-8
[25] Neill, T., et al. (2012) Decorin: A guardian from the ma-
trix. American Journal of Pathology, 181, 380-387.
http://dx.doi.org/10.1016/j.ajpath.2012.04.029
[26] Zafiropoulos, A., et al. (2008) Decorin-induced growth
inhibition is overcome through protracted expression and
activation of epidermal growth factor receptors in os-
teosarcoma cells. Molecular Cancer Research, 6, 785-
794. http://dx.doi.org/10.1158/1541-7786.MCR-07-0165
[27] Zafiropoulos, A. and Tzanakakis, G.N. (2008) Decorin-
mediated effects in cancer cell biology. Connective Tis-
sue Research, 49, 244-248.
http://dx.doi.org/10.1080/03008200802147746
[28] Santra, M., et al. (2008) Ectopic decorin expression
up-regulates VEGF expression in mouse cerebral endo-
thelial cells via activation of the transcription factors Sp1,
HIF1alpha, and Stat 3. Journal of Neurochemistry, 105,
Copyright © 2013 SciRes. OPEN ACCESS