M. Miraula et al. / American Journal of Molecular Biology 3 (2013) 198-203
202
their recombinant expression and purification, as well as
their catalytic and structural characterization are cur-
rently in progress. Importantly, we and others have de-
veloped an arsenal of in vitro inhibitors, mainly against
B1-type MBLs [26], and these compounds will be tested
for their effects against MIM-1 and MIM-2. It is hoped
that in due course a universal inhibitor may emerge from
these and related studies to combat successfully the
threat of antibiotic resistance which poses an immediate
threat to global health.
4. ACKNOWLEDGEMENTS
N. M. thanks the Science Foundation Ireland (SFI) for financial support
in form of a President of Ireland Young Researcher Award (PIYRA)
and G. S. acknowledges the award of a Future Fellowship from the
Australian Research Council (FT120100694) and is grateful to the
National Health and Medical Research Council of Australia for fund-
ing.
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