The Efficacy and Safety of Succinylated Atelocollagen and Adenosine for the Treatment of Periorbital Wrinkles
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atelocollagen-treated and the areas treated with placebo.
However, we did not observe any effects of adenosine on
periorbital wrinkles. This may be due to the small num-
ber of subjects or to the short treatment period.
5. Conclusion
The results of our study show that succinylated atelo-
collagen may be an effective treatment option for perior-
bital wrinkles, but further studies with a longer treatment
period and larger subject group are needed to verify these
results.
REFERENCES
[1] L. Baumann, “Skin Aging and Its Treatment,” The Jour-
nal of Pathology, Vol. 211, No. 2, 2007, pp. 241-251.
doi:10.1002/path.2098
[2] G. J. Fisher, S. Kang, J. Varani, Z. Bata-Csorgo, Y. Wan,
S. Datta and J. J. Voorhees, “Mechanisms of Photoaging
and Chronological Skin Aging,” Archives of Dermatology,
Vol. 138, No. 11, 2002, pp. 1462-1470.
doi:10.1001/archderm.138.11.1462
[3] A. Chiu and A. B. Kimball, “Topical Vitamins, Minerals,
and Botanical Ingredients as Modulators of Environ-
mental and Chronological Skin Damage,” British Journal
of Dermatology, Vol. 149, No. 4, 2003, pp. 681-691.
doi:10.1046/j.1365-2133.2003.05540.x
[4] H. Y. Park, J. K. Youm, M. J. Kwon, B. D. Park, S. H.
Lee and E. H. Choi, “K6PC-5, a Novel Sphingosine
Kinase Activator, Improves Long-Term Ultraviolet Light-
Exposed Aged Murine Skin,” Experimental Dermatology,
Vol. 17, No. 10, 2008, pp. 829-836.
doi:10.1111/j.1600-0625.2008.00708.x
[5] Y. G. Kim, M. Sumiyoshi, M. Sakanaka and Y. Kimura,
“Effects of Ginseng Saponins Isolated from Red Ginseng
on Ultraviolet B-Induced Skin Aging in Hairless Mice,”
European Journal of Pharmacology, Vol. 602, No. 1,
2009, pp. 148-156. doi:10.1016/j.ejphar.2008.11.021
[6] J. Varani, M. K. Dame, L. Rittie, S. E. G. Fligiel, S. Kang,
G. J. Fisher and J. J. Voorhees, “Decreased Collagen Pro-
duction in Chronologically Aged Skin: Roles of Age-
Dependent Alteration in Fibroblast Function and Defec-
tive Mechanical Stimulation,” The American Journal of
Pathology, Vol. 168, No. 6, 2006, pp. 1861-1868.
doi:10.2353/ajpath.2006.051302
[7] G. J. Fisher, T. Quan, T. Purohit, Y. Shao, M. K. Cho, T.
He, J. Varani, S. Kang and J. J. Voorhees, “Collagen
Fragmentation Promotes Oxidative Stress and Elevates
Matrix Metalloproteinase-1 in Fibroblasts in Aged Hu-
man Skin,” The American Journal of Pathology, Vol. 174,
No. 1, 2009, pp. 101-114.
doi:10.2353/ajpath.2009.080599
[8] D. L. Bissett, J. E. Oblong and C. A. Berge, “Niacina-
mide: A B Vitamin that Improves Aging Facial Skin Ap-
pearance,” Dermatologic Surgery, Vol. 31, No. s1, 2005,
pp. 860-865.
[9] J. Varani, D. Spearman, P. Perone, S. E. Fligiel, S. C.
Datta, Z. Q. Wang, Y. Shao, S. Kang, G. J. Fisher and J. J.
Voorhees, “Inhibition of Type I Procollagen Synthesis by
Damaged Collagen in Photoaged Skin and by Colla-
genase-Degraded Collagen in Vitro,” The American Jour-
nal of Pathology, Vol. 158, No. 3, 2001, pp. 931-942.
doi:10.1016/S0002-9440(10)64040-0
[10] G. J. Fisher, S. Datta, Z. Wang, X. Y. Li, T. Quan, J. H.
Chung, S. Kang and J. J. Voorhees, “c-Jun-Dependent
Inhibition of Cutaneous Procollagen Transcription Fol-
lowing Ultraviolet Irradiation is Reversed by All-Trans
Retinoic Acid,” The Journal of Clinical Investigation,
Vol. 106, No. 5, 2000, pp. 663-670.
doi:10.1172/JCI9362
[11] M. Singh and C. E. Griffiths, “The Use of Retinoids in
the Treatment of Photoaging,” Dermatologic Therapy,
Vol. 19, No. 5, 2006, pp. 297-305.
doi:10.1111/j.1529-8019.2006.00087.x
[12] M. Samuel, R. C. Brooke, S. Hollis and C. E. M. Griffiths,
“Interventions for Photodamaged Skin,” Cochrane Data-
base System Review, Vol. 25, No. 1, 2005, CD001782.
[13] M. L. Abella, “Evaluation of Anti-Wrinkle Efficacy of
Adenosine-Containing Products Using the FOITS Tech-
nique,” International Journal of Cosmetic Science, Vol.
28, No. 6, 2006, pp. 447-451.
doi:10.1111/j.1467-2494.2006.00349.x
[14] E. S. Chan, P. Fernandez, A. A. Merchant, et al., “Adeno-
sine A2A Receptors in Diffuse Dermal Fibrosis: Patho-
genic Role in Human Dermal Fibroblasts and in a Murine
Model of Scleroderma,” Arthritis & Rheumatism, Vol. 54,
No. 8, 2006, pp. 2632-2642. doi:10.1002/art.21974
[15] S. Srivastava, S. D. Gorham and J. M. Courtney, “The
Attachment and Growth of an Established Cell Line on
Collagen, Chemically Modified Collagen, and Collagen
Composite Surfaces,” Biomaterials, Vol. 11, No. 3, 1990,
pp. 162-168. doi:10.1016/0142-9612(90)90149-K
[16] J. U. Shin, Y. J. Choi, M. R. Roh, K. Y. Chung and H.
Suh, “Diabetic Ulcers Treated with Bi-Layered Collagen
Membrane,” Korean Journal of Dermatology, Vol. 47,
No. 7, 2009, pp. 831-834.
[17] J. U. Shin, M. R. Roh, D. K. Rah, N. K. Ae, H, suh and K.
Y. Chung, “The Effect of Succinylated Atelocollagen and
Ablative Fractional Resurfacing Laser on Striae Disten-
sae,” Journal of Dermatological Treatment, Vol. 22, No.
2, 2011, pp. 113-121. doi:10.3109/09546630903476902
[18] T. J. Brown, D. Alcorn and J. R. Fraser, “Absorption of
hyaluronan applied to the surface of intact skin,” Journal
of Investigative Dermatology, Vol. 113, No. 5, 1999, pp.
740-746. doi:10.1046/j.1523-1747.1999.00745.x
[19] M. A. Mariggiò, A. Cassano, A. Vinella, et al., “En-
hancement of Fibroblast Proliferation, Collagen Biosyn-
thesis and Production of Growth Factors as a Result of
Combining Sodium Hyaluronate and Aminoacids,” In-
ternational Journal of Immunopathology and Pharma-
cology, Vol. 22, No. 2, 2009, pp. 485-492.
[20] T. Scholzen and J. Gerdes, “The Ki-67 Protein: From the
Known and the Unknown,” Journal of Cellular Physiol-
ogy, Vol. 182, No. 3, 2000, pp. 311-322.
doi:10.1002/(SICI)1097-4652(200003)182:3<311::AID-J
CP1>3.0.CO;2-9