F. S. PELEIAS JR. ET AL.
208
Figure 3. Comparison between seed migration in loose,
mixed and stranded implants [25].
As the number of seeds that migrate is normally no
more than 1%, the efficacy of treatment will hardly be
impaired [27]. However, although no harmful effect due
to seed migration has been observed, the reduction of this
occurrence is highly desirable for Brazilian physicians
[26-28].
4. Conclusion
It can be concluded that the use of stranded seeds in Bra-
zil is far superior to the use of loose seeds (more than 4
times). The main reason is the reduction of the seed mi-
gration events into other parts of the body, since there is
a potential hazard, even considering that no harmful ef-
fect has been observe. The data regarding dosimetry are
still controversial.
REFERENCES
[1] Brasil. Ministério da Saúde, “Estimativa 2010: Incidência
de Câncer no Brasil/Instituto Nacional de Câncer,” 2009.
http://www1.inca.gov.br/estimativa/2010/estimativa2009
1201.pdf
[2] World Health Organization (WHO), “Cancer,” 2010.
http://www.who.int/cancer/en
[3] International Agency for Research on Cancer (IARC),
“World Cancer Report 2008”, 2008.
http://www.iarc.fr/en/publications/pdfs-online/wcr/2008/
wcr_2008.pdf
[4] Brasil. Ministério da Saúde, “Câncer de Próstata.”
http://www2.inca.gov.br/wps/wcm/connect/tiposdecancer
/site/home/prostata
[5] L. J. E. S. Vieira, et al., “Prevenção do Câncer de Próstata
na Ótica do Usuário Portador de Hipertensão e Diabetes,”
Ciência & Saúde Coletiva, Vol. 13, No. 1, 2008.
http://www.scielosp.org/scielo.php?script=sci_arttext&pi
d=S1413-81232008000100019
doi:10.1590/S1413-81232008000100019
[6] R. Gomes, et al., “A Prevenção do Câncer de Próstata:
Uma Revisão da Literatura,” Ciência & Saúde Coletiva,
Vol. 13, No. 1, 2008, pp. 235-246.
doi:10.1590/S1413-81232008000100027
[7] P. A. Balter; J. F. Aguirre and W. F. Hanson, “Practical
Considerations for the Calibration of Low Energy/Low
Activity Seeds,” World Congress on Medical Physics and
Biomedical Engineering, Vol. 4, 23-28 July 2000, pp.
2761-2764.
[8] L. Zuofeng, “Monte Carlo Calculations of Dosimetry
Parameters of the Urocor Prostaseed I-125 Source,”
Medical Physics, Vol. 29, No. 6, 2002, pp. 1029-1034.
doi:10.1118/1.1478559
[9] T. Romero, “Radioterapia Para Câncer de Próstata Ganha
Prêmio International,” 2009.
http://www.diariodasaude.com.br/news.php?article=radiote
rapia-cancer -prostata-ganharemio-internacional&id=4410
[10] C. A. Zeituni, “Dosimetria de Braquiterapia,” Ph.D The-
sis, University of São Paulo, São Paulo, 2010.
http://pelicano.ipen.br/PosG30/TextoCompleto/Carlos%2
0Alberto%20Zeituni_D.pdf
[11] M. E. C. M. Rostelado, “Estudo e Desenvolvimento de
uma Nova Metodologia para Confecção de Sementes de
Iodo-125 Para Aplicação em Braquiterapia,” Ph.D Thesis,
University of São Paulo, São Paulo, 2005.
http://pintassilgo2.ipen.br/biblioteca/teses/23214.pdf
[12] J. F. Williamson, “On the Dosimetric Influences of
Air-Kerma Strength Calibration Geometry and Internal
Source Structure for Pd-103 and I-125 Brachytherapy
Sources,” World Congress on Medical Physics and Bio-
medical Engineering, Vol. 1, 23-28 July 2000, pp. 368-
371.
[13] J. J. Blasko, M. J. Datolli and K. Wallner, “Prostate
Brachytherapy,” Smart Medicine, 1997.
[14] C. A. Franca, et al., “The Seven-Year Preliminary Results
of Brachytherapy with Iodine-125 Seeds for Localized
Prostate Cancer Treated at a Brazilian Single-Center,”
International Brazilian Journal of Urolpgy, Vol. 33, No.
6, 2007, pp. 752-762.
doi:10.1590/S1677-55382007000600003
[15] J. Varregoso, “Braquiterapia Prostática,” Acta Urológica,
Vol. 23, 2006, pp. 21-30.
http://www.apurologia.pt/acta/3-2006/braquit-prost.pdf
[16] J. J. Batterman, et al., “Results of Permanent Prostate
Brachytherapy, 13 Years of Experience at a Single Insti-
tution,” Radiotherapy and Oncology, Vol. 71, No. 1, 2004,
pp. 23-28. doi:10.1016/j.radonc.2004.01.020
[17] C. M. Agrawal and J. E. Lin, “Synthetic Bioabsorbable
Polymers for Implants,” ASTM Special Technical Publi-
cations, Pensilvânia, 2000. doi:10.1520/STP1396-EB
[18] Inion Ltd., “Sport Medicine: General FAQ,” Inion Ltd.,
London, 2012.
[19] D. Fuller, J. J. Koziol and A. C. Feng, “Prostate Brachy-
therapy Seed Migration and Dosimetry: Analysis of Strand-
ed Sources and Other Potential Predictive Factors,” Brachy-
therapy, Vol. 3, 2004, pp. 10-19.
doi:10.1016/j.brachy.2004.02.003
Copyright © 2012 SciRes. OJU