sb">tive activity. As our knowledge of the neuroendocrine
factors develops, in the future our focus will be to deter-
mine how they interact with other prostate cell types that
reside in the dynamic prostatic microenvironment. Inves-
tigation of how NE factors and the resulting downstream
signaling pathways contribute to the initiation and the
progression of PCa should be pursued and will help iden-
tifying new therapeutic tools to block or prevent PCa
The NE axis remains an important therapeutic target
for drug development in advanced PCa. Development of
new generation of drugs directed against NE-like cells
may help targeting populations of PCa cells that may be
resistant to traditional therapies, thus helping setting up
individualized therapy which takes into account the het-
erogeneity of PCa.
Financial & Competing Interests Disclosure
Work performed in the laboratory of the author has been
supported by the University of Rouen. The author has no
other relevant affiliation or financial involvement with
any organization or entity with a financial interest in or
financial conflict with the subject matter or materials
discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of
this manuscript.
7. Acknowledgements
I thank Dr. Léna Diaw (NIH/NHLBI, USA) for critical
reading of the manuscript.
Copyright © 2012 SciRes. OJU
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