R. R. Tampi et al. / Advances in Alzheim er’s Disease 1 (2012) 13-16
67 Dementia; Lewy
coccygeal decubitus, resolving,
dysphagia secondary to deme ntia no Gabapentin
20 mg Donepezil
83 Demen tia; mixed
recurrent UTI, CVA with
hemiplegia and aphasia, AF,
59 Dementia; AD
type, severe hypertension no
37.5 mg Valproic acid
AD type GERD, Parkinson’s disease,
BAD type II,
77 Dementia; mixed type
(AD and Vascular),
IDDM, hypertension, GERD,
phimosis & balanitis with penile
discharge positive for MRSA no Gabapentin
200 mg Quetiapine
AD = Alzheimer’s Disease; CVA = Cerebral Vascular Accident; CAD = Coronary Artery Disease; CRI = Chronic Renal Failure; MI = Myo-
cardial Infarctus; BPH = Benign Prostate Hypertrophy; UTI = Urinary Tract Infection; CHF = Chronic Heart Failure; NIDDM = Non-Insulin
Dependent Diabetes Mellitus; MRSA= Methicillin Resistant Staphylococcus aereus; GERD = Gastroesophageal R e f l ux D i se a s e ; A F = Atrial
Fibrillation; MDD = Major Depressive Disorder; BAD = Bipolar Affective Disorder.
psychotic medication and gabapentin, which appears to
be effective and well tolerated in the treatment of BPSD.
Gabapentin was also effective as monotherapy for the
treatment of two cases of BPSD. Side-effect profile was
relatively benign and no drug-drug interactions were
noted. Our finding is in keeping with the case-series by
Moretti et al. , Herrmann et al. , where they found
that gabapentin monotherapy was well tolerated and ef-
fective for the treatment of BPSD. However, our study
also indicated that gabapentin was well tolerated even in
combination with atypical antipsychotics.
As this study is a retrospective chart review and has
potential for bias, further controlled studies are necessary
to confirm the efficacy of the combination treatments for
BPSD. However, this current study provides the proof
that elderly patients with BPSD tolerate a combinatio n o f
psychotropic medications, if these medications are dosed
appropriately and monitored carefully.
Behavioral and psychological symptoms are common
in dementia. The treatment for these important symptoms
is not standardized and is limited by the side-effect pro-
file of the various drugs. Gabapentin, an anticonvulsant
medication may be beneficial in combination with an-
tipsychotic agents or as monotherapy for patients pre-
senting with these behaviors.
 Barucha, A.J., Rosen, J., Mulsant, B.H. and Pollock, B.G.
(2002) Assessment of behavioral and psychological
symptoms of deme ntia. CNS Spectrums, 7, 797-802.
 Lawlor, B. (2002) Managing behavioural and psycho-
logical symptoms in dementia. British Journal of Psy-
chiatry, 12, 463-465. doi:10.1192/bjp.181.6.463
 Tampi, R.R. and Van Dyck, C.H. (2006) Behavioral and
psychological symptoms of Alzheimer’s disease. In:
Miao-Kun, S., Ed., Research Progress in Alzheimer’s Dis-
ease, Nova Science Publishers, Hauppauge, New York,
 Sink, K.M., Holden, K.F. and Yaffe, K. (2005) Pharma-
cological treatment of neuropsychiatric symptoms of de-
mentia: A review of the evidence. Journal of American
Medical Associati on, 293, 596-608.
 Birnbaum, A.K. (2007) Pharmacokinetics of antiepileptic
drugs in elderly nursing home residents. International
Review of Neurobiology, 81, 211-220.
 Moretti, R., Torre, P. and Rodolfo, M.A., et al. (2003)
Gabapentin for the treatment of behavioural alterations in
dementia. Drugs Aging, 20, 1035-1040.
 Herrmann, N., Lanctot, K. and Myszak, M. (2000) Effec-
tiveness of gabapentin for the treatment of behavioral
disorders in dementia. Journal of Clinical Psychophar-
macology, 20, 90-93.
 Quick Reference to the Diagnostic Criteria from
DSM-IV-TR™ (2000) American Psychiatric Association,
Washington DC, 88-95.
 Folstein, M., Folstein, S. and McHugh, P. (1975) Mini-
mental state: A practical method for grading the cognitive
state of patients for the clinician. Journal of Psychiatric
Research, 12, 189-198.
Copyright © 2012 SciRes. OPEN A CCESS