tential antiaggregant activity [72]. Protective effects of fish have been extended to cancer, aging and Alzheimer’s disease [73] It supplies excellent amount of proteins, low saturated fats, long-chain and omega-3 polyunsaturated fatty acids (PUFA). This topic gained a great attention after the observations regarding the myocardial preconditioning [74]. At this regard, diet and healthy lifestyle (that is, for example, a regular physical activity [75]) are actually considered the most powerful preconditioners to reduce the ischemic myocardial damage. Among dietary factors, a diet with an increased omega-3 PUFA intake and a poor consumption of saturated fatty acids and omega-6 PUFA showed the best results in myocardial protection against ischemic injury [76]. The Mediterranean diet typically has a fatty acids profile very similar to the ideal one. Moreover, the lack in this diet of great amounts of omega-6 PUFA is more interesting if we consider that these fatty acids showed strong effects in enhancing breast cancer [77].

4. Conclusions

A regular and moderate wine consumption, associated with a simple, healthy diet such the Mediterranean one, is an advisable life habit. Beyond theoretical hypotheses, polyphenols could find clinical applications and in fact resveratrol tablets are already available as antiviral.

More recently, resveratrol and quercetin have been employed in developing drug-eluting polymer coatings for endovascular devices. The gradual release of therapeutical concentration of these agents is useful to avoid the in-stent stenosis [78].

In light of all these considerations, a regular and moderate wine consumption, (The so called “Mediterranean way of drinking” of Giocosa and coworkers [79]) accompanied by Mediterranean-style diet and physical activity could be considered a wise prescription for healthy and ill people. At this regard, to seal its fundamental role in preventive strategies, Mediterranean diet obtained in 2010 the acknowledgment of UNESCO as an Intangible Cultural Heritage of Humanity.

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NOTES

*Corresponding author.

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