S. Jiao et al. / J. Biomedical Science and Engineering 3 (2010) 317-321

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321

empirical method. The results also show that our esti-

mator provides more stable and accurate estimates of the

FDR. The advantage of our method is more evident in

the case when DE genes are not well separated with EE

genes and the variances of expression levels for every

gene are different. This is due to the fact that the permu-

tation FDR estimator is more easily affected by the sam-

pling variability.

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