Background: Uterine Didelphys is a rare congenital condition and it can affect both mother and fetus. A 24 year-old patient presented to the emergency room with pelvic pain and a pelvic ultrasound confirmed the presence of Uterine Didelphys. She subsequently became pregnant and was first seen at 21 weeks gestation. She was designated as a high-risk patient during the second trimester when she experienced irregular contractions. She was monitored weekly with Non-Stress Tests and eventually was delivered by Cesarean Section. Uterine Didelphys can be detected in-utero in affected individuals, and clinical findings vary among individuals. Some may be asymptomatic, whereas others will experience dyspareunia, and still others may present with concurrent renal agenesis. Serial sonograms are performed throughout their pregnancy to evaluate fetal growth and well-being, as well as cervical length. Unlike many uterine anomalies, Uterine Didelphys does not affect fertility but can affect labor, fetal growth, placentation, fetal viability and fetal outcome. Uterine Didelphys frequently results in recurrent miscarriages and may cause preterm labor and necessitate cesarean section. The presentation, associated symptoms, methods of detection and management options for Uterine Didelphys will be discussed.
Grigoris estimates that congenital uterine malformations may occur in up to 4.3% of women. It is reported that less than half of all pregnancies in patients with Uterine Didelphys (UD) result in a live birth. Up to 1 in 3 pregnancies end in abortion, about half end in premature deliveries, and the overall chance of a pregnancy reaching term is about 1 in 5 [
A 24 year-old patient developed pelvic pain and the evaluation included a pelvic sonogram which revealed UD. When examined, she was found to have two full uteri and two full cervices but only one vagina and no vaginal septum.
Shortly after that, the patient became pregnant. She presented at 21 weeks gestation at which time the fetus was noted to be growing normally in the right uterine horn. During the second trimester, she experienced several episodes of irregular contractions and was treated for a urinary tract infection. At 31 weeks she presented for weekly Non-Stress Testing and repeated ultrasounds for fetal growth.
Her estimated due date was determined from her ultrasound evaluation at 21 weeks. At this visit at 31 weeks, the patient confirmed fetal movement but denied any vaginal bleeding or loss of fluids. She denied any pelvic pain or discomfort, abdominal pain, dyspareunia, or any previous miscarriages. She denied the presence of other medical problems, other surgical history, and any hospitalizations. She was taking only prenatal vitamins. She denied smoking, drinking, drug use, and denied any medicinal or seasonal allergies. The review of systems was normal for all systems. On physical exam, the patient was found to have normal vital signs and her physical exam was remarkable only for the gravid uterus which extended 32 cm. above the symphysis pubis. The lower extremities were not edematous.
The remainder of the pregnancy progressed without incident. She presented at 39 weeks 3 days gestation to the labor room and a tracing showed good fetal reactivity. An induction of labor was attempted but the tracing grew increasingly worrisome and the patient complained of decreased fetal movement. A fetal tracing now showed variable decelerations. She was consented for Cesarean Section, an epidural was placed, and a “J” incision was made on the uterus to access the infant. The pediatricians were present to assist with the delivery of the infant weighing 2725 grams and the APGAR scores were 9 at one minute and 9 at five minutes. Uterine atony was noted after delivery and the patient was treated with Pitocin, Methergine, Cytotec, and Hemabate with a good results. The placenta was consistent with a late term placenta; the cord was trivascular; and an infarct involving less than 5% of the placenta was noted. The patient had a prolonged hospital course and was discharged home on post-operative day nine.
At the first postnatal visit, she was noted to be in good spirits with a normal incision and a report that the baby was doing well.
Uterine Didelphys is a rare congenital condition occurring in up to 4.3% of the women in the general population, and it can affect a mother and her fetus [
There are two main UD variations: UD unicollis and UD bicollis. Unicollis is more common, and it describes affected individuals where two uteri are connected to each-other within the cervix with only one vagina. Bicollis describes an individual that has two uterine cavities, each with its own cervix and vagina and no communication between them [
UD is commonly associated with Renal Agenesis or other abnormalities like
pelvic kidney. A vaginal septum is present in 75% of UD patients, and if the septum is transverse within the vaginal canal then it can cause obstruction of labor [
UD can resemble other congenital malformations on physical examination, particularly a septate uterus or a bicornuate uterus. There are a few key differences that can help differentiate the latter two conditions from UD. A septate uterus has a normal fundal contour but has a persistent longitudinal septum which can partially (partial) or completely (complete) divide the uterine cavity. A bicornuate uterus is a partial failure of fusion of the ducts which then results in one uterus divided into two horns. Similar to a septate uterus, a bicornuate uterus can be designated as complete or partial and can additionally be categorized as bicollis and unicollis. See
UD is primarily detected via hysterosalpingogram (HSG) as it is a readily available and cost-effective detection method. Some complications may occur with HSG, most notably bleeding and/or infection. An ultrasound may also be utilized for UD detection as it is readily available and cost-effective, but the image provided is not as clear as with an HSG. An MRI is the gold standard for UD detection, but it is less commonly performed due to it being less accessible and having
a higher associated cost to perform [
In pregnancy, a patient with a uterine anomaly should be referred and followed by a maternal fetal medicine specialist. The patient should be counseled about premature labor, abnormal placentation, abnormal lie, fetal growth restriction, abnormal labor progression, and possible Cesarean section. Serial sonograms should be performed on a monthly basis in order to evaluate fetal well-being and growth, and to assess the mother’s cervical length. Weekly non-stress tests are recommended in the third trimester. Through early detection and proper management, a UD mother optimizes her chances of having a full-term pregnancy.
We would like to thank our patient who agreed to having her story told and Michele Follen, MD, PhD, for her teaching and encouragement.
The authors declare no conflicts of interest regarding the publication of this paper.
Paknejad, O., Bryant, D., Peterkin, C. and Wilcox, W. (2018) Uterine Didelphys in a Pregnant Mother. Open Journal of Obstetrics and Gynecology, 8, 1423-1430. https://doi.org/10.4236/ojog.2018.813143