There is increased incidence of cancer worldwide but much of the burden of morbidity and mortality will occur in the developing world because of cancer associated infectious diseases of which HIV infection carries a large proportion. Site-based studies show that proportion of late stage cancer presentation range between 60% - 92% in the last 10 years. There is paucity of information on reasons for the late presentation. This study is aimed to find out the factors associated with delay in presentation of symptomatic cancers among HIV infected persons in Plateau State, Nigeria. A mixed method study consists of quantitative and qualitative component. Participants were sampled from HIV infected persons diagnosed with cancer and referred to the Oncology unit. Variables on Patient and health service factors associated with late presentation of cancers were collected. Quantitative data was analyzed using Epi info version 3.5.3 and Microsoft Excel while thematic analysis was done for qualitative data. There were 503 respondents and the mean age was 48.7 ± 13.5 years. Male sex OR 2.5, (P = 0.002); Farming occupation OR 1.7, (P = 0.0005) and Primary education OR 2.0, (P = 0.0005) were associated with delay. Majority of respondents 349(69%) presented more than six months after onset of symptom. Common symptoms were pain 462(45.70%), swelling 237(23.44%) and skin discoloration 210(20.77). Their Initial reaction was mainly the use of alternative remedies 234(46.5) CI 42.1 - 51.0. Up to 274(54.47%) of participants obtained diagnosis 3 months after presenting to a health facility. Laboratory related issues 199(39.56%) and long booking time 163(32.40%) were the most common reasons for delay. Delay was found to be both patient and services related. The study also suggests that cancer symptom awareness is poor among the participants. There is no tangible cancer prevention program in the HIV/AIDs treatment program. A more in-depth knowledge of cancer is required for both the sufferer and the care giver.
Cancer is becoming the leading cause of death worldwide, with about 16.1% of these cancers found to have been linked to certain infection [
HIV is one of the viral infections implicated in “infection induced cancers” and a person infected with HIV has higher risk of developing cancer and dying from it compared to non infected persons [
Cancer occurring in an individual with background HIV infection has been reported to be very aggressively compounded by the low immunity. Granted that the introduction of the Highly Active Antiretroviral Therapy (HAART) for HIV treatment can rise the immune system to normal levels following appropriate and consistent use, the immune system still remains damaged in its molecular components rendering the individual susceptible to developing cancer [
Treatment of cancer in the general population even in the best hospitals until recently has remained difficult and associated with high mortality all over the world. A multidisciplinary and multimodal approach to cancer treatment using a combination of “Early Detection” through various screening techniques and “Targeted Evidence Based Treatment” has improved the outcome [
Report on the pattern of cancer presentation in Nigeria however reviled that about 80% - 85% of common malignancies in Nigeria presented late with a mortality of about 90% associated with the late stage disease presentation in the patients. Reasons for the late presentation ranged from Ignorance, lack of awareness of cancer, low socioeconomic status, myths about cancer compounded by lack of trained personnel in the field of cancer and inadequate hospitals equipped for cancer management lead to the delay in diagnosis [
Although HIV infection is known to increase the risk of cancer in infected persons, little is known about cancers among our HIV infected patients, if they present late and the reasons for the delay. We analyzed the length of time it takes to initiation definitive cancer treatment for HIV infected persons with cancer in Plateau State from the time symptom was first noticed.
A mixed method study design, consisting of qualitative and a quantitative component. The study protocol was approved by the ethical review board of the Jos University Teaching Hospital, Faith alive Foundation Hospital Jos, the Nigeria Field Epidemiology and Laboratory Training Program (NFELTIP) and Center for Disease Control USA in Nigeria.
Consenting participants were sampled from HIV infected persons who were already diagnosed with cancer and those with symptoms suggestive of cancer referred from the various HIV treatment facilities to the Jos University Teaching Hospital. Cancer patients presenting to the Oncology unit for treatment who were diagnosed HIV positive during routine work up investigations were also enrolled. Histological diagnosis was done for suspected cases. Case files at referral centers were consulted to confirm diagnosis for participants with multiple cancers who could not give correct information about the primary cancer they had.
Informed consent was obtained from all participants. Data was analyzed using Excel version 6.0 and Epi info version 3.4.5.
There were 505 respondents, Males were 252(50.1%) and females 251(49.9%). Majority (45%) were in the age range 36 - 55 years and the mean age was 48.7 ± 13.5 years. Most of the respondents 432(85.9%) were married, 362(74%) were self-employed while 141(26%) were government workers. Majority of the respondents, 401(93%) had some education ranging from Primary school to Degree level, only 37(7.4%) did not have any formal education. Logistic regression showed that there was significant relationship between socio-demographic factors and late presentation of cancer: Age range 36 - 45 years OR 2.7, (P = 0.0005); Male sex OR 2.5, (P = 0.002); Farming occupation OR 1.7, (P = 0.0005) and Primary education OR 2.0, (P = 0.0005). Religious affiliation was not a significant factor (P = 0.115). Commonest cancer was Kaposi sarcoma 173(31.63%) followed by Breast cancer 89(16.27%), Prostate cancer 74(13.53%), Bladder cancer 44(8.95%), Colonic cancer(6.97%) and Cervical cancer 24(4.38%) ranked 5th in descending order while the least frequent was Thyroid and lung cancer 2(0.36%) each. The most frequent symptoms among respondents was pain 462(45.70%) followed by swelling 237(23.44%) and skin changes 210(20.77). Delay from first time symptom was noticed to first presentation to health facility was 11(27%) delayed 0 - 3 months, while 123(29%) delayed 3 - 6 months and 349(69%) delayed > 6 months (
Analysis of the type of cancers found among HIV respondents indicated that Kaposi sarcoma 173(31.63%) was the commonest occurring cancer among the respondents, however 44(8.04%) respondents had multiple cancers (
Health facility visit on account of cancer related symptoms
Patient mediated treatment actions
Laboratory related issues 199(39.56%) and Long booking time 163(32.40%) were the most common reasons for delay in initiating treatment (
The main founding in this research is there was delay in presentation of cancers among the study population. Using a modified Andersen’s model, Phase one delay was due to “Patient mediated factors”; Phase two and three delay was “service mediated”.
Patient mediated delay
Types | Frequency | Percent (%) |
---|---|---|
Kaposi sarcoma | 173 | 31.63 |
Breast cancer | 89 | 16.27 |
Prostate cancer | 74 | 13.52 |
Cancer of the bladder | 49 | 8.95 |
Colonic cancer | 38 | 6.94 |
Cervical cancer | 24 | 4.38 |
Endometrial cancer | 17 | 3.10 |
Soft tissue sarcoma | 14 | 2.55 |
Testicular cancer | 12 | 2.18 |
Squamous-cell carcinoma | 12 | 2.18 |
Ovarian cancer | 10 | 1.82 |
Liver cancer | 10 | 1.82 |
Pancreatic cancer | 9 | 1.63 |
Gastric cancer | 8 | 1.44 |
Renal cancer | 6 | 1.09 |
Esophageal cancer | 4 | 0.72 |
Penile cancer | 4 | 0.72 |
Lung cancer | 2 | 0.36 |
Thyroid cancer | 2 | 0.36 |
Melanoma | 2 | 0.36 |
In phase one, majority of the respondents experienced their symptoms for more than 3 months before seeking medical attention at a health facility. This could be due to the way individual interpret symptoms which leaded to taking appropriate action. In this study, some of the symptoms participants experienced were vague, not unusual in HIV infection and therefore might not have been regarded as a sign of a more serious health problem. This agrees with Whitaker,
Reason for delay | Frequency | Percent (%) | 95% Confidence Limits |
---|---|---|---|
Tried Alternative remedies | 234 | 46.5 | 42.1 - 51.0 |
Symptom considered not serious problem | 43 | 8.5 | 6.3 - 11.4 |
Fear of unknown | 45 | 8.9 | 6.7 - 11.9 |
Lack of funds | 87 | 17.3 | 14.2 - 21.0 |
Visit chemist | 52 | 10.3 | 7.9 - 13.4 |
Self-medication | 24 | 4.8 | 3.1 - 7.1 |
Traditional belief | 18 | 3.6 | 2.2 - 5.7 |
Katriina L who reported in their study that symptoms that occur in daily life are not usually regarded to be related to cancer [
Pain and swelling were however strong reasons for seeking medical attention among the participants. Increasing intensity of pain, increasing size of a mass among others were strong reasons to abandon alternative measure and to seek medical help. This finding is supported by a study reported by Whitaker KL where they found pain (72%) and lump (70%) were associated with highest level of help seeking [
Majority of respondents delayed due to preference for alternative methods of treatment first.
Traditional beliefs about cancer is known to play an important role in the African setting such as stated by some responds “I believe cancer is a disease that cannot be treated by medical doctor therefore it’s no use visiting a doctor” could have influenced their choice of alternative treatment first. This agrees with the study of Ibrahim N.A. et al., they found believe in spiritual healing to be one of the major reason for delay among women with breast cancer [
Service mediated delays
Participants experienced considerable delay after presenting to health facilities. Reasons for delay ranged from long turnaround of diagnostics investigations and complementary investigations. Others were long booking time due to high patients load and appointments times. Reasons for missed appointments ranged from workers strikes, to public holidays falling on appointment days when clinics are not open to patients. Pace et al. found similar result in their study among breast cancer patients in Rwanda. They reported a median system delay of up to 5(five) months and it was significantly associated with more advanced disease [
Another important factor is that the first doctor patient came in contact with at the primary or even secondary health care did know what to do. Macleod and his colleagues also reported in their study that significant factor for system delay was failure of the practitioner to recognize symptoms and to act appropriately which also supports our findings [
1) There is no standard definition of late presentation of cancer therefore “Patient and Provider delay of three months from the time patient first noticed a symptom to first presentation at a health facility” was adopted for this study.
2) Stage of the disease was not used in this study because there was lack of required instruments for accurately staging the disease.
3) There was possibility of recall bias and some patients were not sure of the type of cancers they had. Case notes were then used to extract information and sometimes inconclusive due to lose sheets.
The factors for delay in our study are intricately inter-related. The study also suggests that cancer symptom awareness is poor among the participants. There is no tangible cancer prevention program in the HIV/AIDs treatment program. A more in-depth knowledge of cancer is required for both the sufferer and the care giver.
We acknowledge the support Centre for Disease Control (CDC) USA, CDC Nigeria, Nigeria Field Epidemiology and Laboratory Training Program (NFELTIP), Adekunle Victor the medical student who was lead in data collection. This study was partly funded by the Centre for Diseases Control USA.
Isichei, M.W., Misauno, A.M., Ale, F.A., Isichei, C.O., Abubakar, A., Sabitu, K., Nguku, P. and Anyawu, P. (2017) Factors Associated with Delay in Presentation of Symptomatic Cancers among HIV Infected Persons in Plateau State, Nigeria. World Journal of AIDS, 7, 157-165. https://doi.org/10.4236/wja.2017.73013