Objectives: To present the effect of intravitreal ranibizumab (IVR) therapy combined with sulfotanshinone sodium (SS) injection in a patient suffering from type II optic disc vasculitis (ODV). Methods: A 26-year-old female patient was diagnosed with type II ODV with macular edema (ME). The information was obtained by complete medical and ophthalmic history taking and a detailed ophthalmic examination at the initial and follow-up visits. Functional and morphological outcomes at baseline, 1 week and 1 month following IVR+SS injections, are presented. Results: Best-corrected visual acuity (BCVA) improved from 78 letters (ETDRS) at baseline to 90 letters at 1-week follow-up and maintained stable through 1-month follow-up. Central retinal thickness (CRT) measured by optical coherence tomography (OCT) decreased from 465 μm at baseline to 240 μm at 1-week follow-up and to 226 μm at 1-month follow-up. Mean deviation (MD) measured by perimetry increased from ?5.17 dB to ?4.59 dB and to ?4.29 dB, respectively. Fluorescein angiography (FFA) showed that the initial macular edema at baseline disappeared while the arm-retina circulation time (ART) was also greatly shortened when compared to the baseline. Electroretinogram (ERG) measured at 1-month follow-up demonstrated an overall improvement of the retinal function after the injection. No ocular or systemic side effects were detected. Conclusions: IVR+SS injection may lead to resolution of the associated ME and improve the retina morphologically as well as functionally. To our knowledge, this is the first case of a type II ODV benefiting from treatment with IVR+SS injection. The observed results warrant further investigation.
Optic disc vasculitis (ODV) is an uncommon, chronic and self-limiting disorder characterized by unilateral optic disc swelling and minimal visual symptoms, seen mostly in young adults with no gender predilection [
This 26-year-old female patient presented with obvious ME, exudation and hemorrhage with no big improvement after hormone therapy. Considering the similarities between these two diseases, we intended to apply our previous clinical experience in treating RVO patients on this patient.
Intravitreal injections of ranibizumab have been shown to be an effective treatment option for RVO patients [
The information was obtained by complete medical and ophthalmic history taking and a detailed ophthalmic examination at the initial and follow-up visits.
Best-corrected visual acuity (BCVA) was 100 letters (ETDRS) OD and 78 letters OS at baseline. Anterior segment examination showed normal findings. Intraocular pressure (IOP) was 15 mmHg bilaterally. Fundus examination showed diffuse optic disc edema with flame-shaped hemorrhages, macular exudation and hemorrhage as well as the twisting and dilation of the retinal veins in LE. Fundus examination showed normal findings in RE. Fluorescein angiography (FFA) demonstrated optic disc swelling, intraretinal hemorrhage and macular edema in LE. The arm-retina time (ART) was also obviously prolonged. The findings in RE were normal. Automated perimetry showed, in LE, a minimum defect linked with physiologic scotoma. Central retinal thickness (CRT) was measured by optical coherence tomography (OCT) as 465 μm. Electroretinogram (ERG) was also done to have an overall idea of the retinal function.
This 26-year-old female patient was treated with one IVR injection combined with SS injections (20 mg per day, five days consecutively in one week, 4 weeks). Written consent for the use of IVR therapy was obtained from the patient and a Ranibizuman (0.5 mg in 0.05 ml) (Lucentis, Genentech Inc.) was applied to the patient’s left eye. SS injection (5 mg/ml) (batch number: H120921) manufactured by the First Biochemical Pharmaceutical Co. Ltd., Shanghai, China, is approved by State Food and Drug Administration of China. SS injection was given diluted at the point of treatment in 250 ml 5% glucose injection for intravenous administration.
In addition to the treatment medicines, usages of any other traditional Chinese medicine or Western medicine were prohibited.
Except that FFA and ERG were done at one-month follow up, other examinations were repeated at one-week and one-month follow up.
At 1 week following the IVR+SS injection, BCVA improved from 78 letters (ETDRS) at baseline to 90 letters at 1-week follow-up and maintained stable through 1-month follow-up. The CRT measured by OCT decreased from 465 μm at baseline to 240 μm at 1-week follow-up and to 226 μm at 1-month follow-up. Mean deviation (MD) measured by perimetry increased from −5.17 dB to −4.59 dB and to −4.29 dB, respectively (
BCVA (letters) | CRT (µm) | MD (dB) | |
---|---|---|---|
Initial | 78 | 465 | −5.17 |
1 week | 90 | 240 | −4.59 |
1 month | 90 | 226 | −4.29 |
Rod b | Max a | Max b | Max b/a | Osz total | Cone a | Cone b | Cone b/a | 30 Hz Amp | |
---|---|---|---|---|---|---|---|---|---|
Initial | 59.6 | 206 | 439 | 2.1 | 162 | 49.5 | 153 | 3.1 | 46.4 |
1 month | 199 | 210 | 516 | 2.5 | 178 | 50.3 | 165 | 3.3 | 48.8 |
Optic disc vasculitis (ODV) is an uncommon, chronic and self-limiting disorder characterized by unilateral optic disc swelling and minimal visual symptoms, seen mostly in young adults with no gender predilection [
Type II ODV is usually misdiagnosed as central retinal venous occlusion (CRVO) for they share quite similar clinical pictures. However, the treatment and prognosis of them are different. Type II ODV is due to retinal phlebitis, so it exists mainly in young adults without hypertension, arteriosclerosis, diabetes mellitus or other systemic diseases with slightly impaired vision and good prognosis. Patients are usually sensitive to hormone therapies. Whereas, CRVO is due to arteriosclerosis, so it is mainly seen in elder adults with hypertension, arteriosclerosis, diabetes mellitus or other systemic diseases with evidently decreased eye sights and poor prognosis. Hormone therapies do not help.
This 26-year-old female patient, after hormone therapy for about two months, started to develop obvious macular edema, exudation and hemorrhage. Although her visual function was relatively good when she first came, the prognosis could be really bad if the ME progressed without any treatment. Current treatment options for patients suffering from type II ODV have limited visual outcomes. Considering the presence of severe ME, exudation and hemorrhage and considering the fact that this patient would not have benefited from either primary corticosteroids or further observation without treatment, we intended to combine the most up-to-date treatment therapy of RVO with SS injections based on our previous clinical experiences to try on this patient to avoid potentially poor visual outcome.
Current treatment options for RVO mainly include laser coagulation and anti-vas- cular endothelial growth factor (VEGF) therapy [
Danshen is considered to promote blood circulation for removing blood stasis and improve microcirculation. It has been widely used to treat cardiovascular diseases for more than 2000 years in China. TSA is an herbal monomer with a clear chemical structure, isolated from Danshen. Previous animal studies have found that compound Danshen dripping pills could be a promising method for the treatment of ischemic retinal disorders through reducing oxidative stress [
We treated this patient with one IVR injection combined with SS injections to see its effect on her ME and her entire retina function. The results demonstrated the efficacy of IVR+SS therapy in reducing ME. The ERG and perimetry results also showed that this treatment could significantly improve this patient’s retinal function and visual function.
To our knowledge, this is the first patient who was treated with IVR+SS injection therapy for type II ODV. The result of this case showed rapid decrease in CRT and visual improvement with one-month follow up so far. Considering the strength of evidence, a long time follow-up need to be conducted in this investigation to assess the effect of this treatment method, and more rigorously designed trials are required for assessing the clinical application of this combined therapy to treat type II ODV patients.
In summary, IVR injection and SS injection together could effectively improve the visual acuity and rapidly alleviate the edema in this type II ODV patient.
Lu, B.W., Wu, X.W. and Zhang, L. (2016) Intravitreal Ranibizumab Combined with Sulfotanshinone Sodium Injection in Treating Type II Optic Disc Vasculitis. Case Reports in Clinical Me- dicine, 5, 494-499. http://dx.doi.org/10.4236/crcm.2016.511062