Introduction: Colorectal gastrointestinal stromal tumors (GISTs) mesenchymal tumor is very uncommon. GISTs effect mostly on the stomach and small intestine and rarely occur in the colon, rectum and esophagus, that originating from precursors of the interstitial cells that originate of Cajal. The symptoms of gastrointestinal stromal tumor depend on the site and size of the tumor, and may include abdominal pain, gastrointestinal bleeding or signs of obstruction; small tumors may, however, be asymptomatic. Some of the patients with gastrointestinal stromal tumor have bloody stools, obstruction and abdominal pain as the commonest manifestation. Immunocytochemical staining for CD117 is helpful in confirming the diagnosis. Case presentation: We report 3 new cases of GISTs: two occurred at the rectal and the other at descending Colon. Two cases are over 50 years of age and, and all cases the chief complain of bowel obstruction, abdominal pain in two cases, and one case with anemia and urine retention. All the patients were operated and were permormed pathology examinatiom. All case ware positive result for immunocytochemical staining CD117. All cases we had presented had size more than 5 cm are considered as unfavorable prognostic factors to Fletcher criteria, all patients scheduled for chemotherapy with Glivec but just one patient continued to used Glivec. Post surgery follows up one patient post milles with urinary incontinence complaints found and that patients are trained to CIC (intermittent catheterization). Conclusion: Colorectal gastrointestinal stromal tumors are very rare and can present as mass abdomen. Resection and chemotherapy are the treatment of choice.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Colonic and rectal gastrointestinal stromal tumors (GISTs) are very uncommon. Gastrointestinal stromal tumors (GISTs) are a heterogeneous group of mesenchymal tumors that arise from the gastrointestinal tract, and have been the cause of much confusion as to their origin, classification, biological behavior and prognosis. They have been called by many names such as STUMP (smooth muscle tumors of uncertain malignant potential), GANT (gastrointestinal autonomic nerve tumors), and GIPACT (gastrointestinal pacemaker cell tumors) in the past. However, advances in immunohistochemistry and electron microscopy have shown that these tumors originate from interstitial cells of Cajal (ICC) or stem cells differentiating towards the ICC. Seventy percent to 80% of GISTs are benign, and such tumors are often found incidentally at surgery and excised in the same session. Approximately 20% to 30% of GISTs are malignant, and these neoplasms are identified based on their mitotic index, tumor necrosis index, and Ki-67 index (which reflects expression of the 395 kDa nuclear antigen MIB-1) [
Histologically GISTs vary from spindle cell tumors to epithelioid and pleomorphic tumors. Most GISTs (95%) express Kit (CD117), CD34 (70%), and heavy caldesmon (80%), whereas 25% are positive for smooth muscle actin and less than 5% for desmin. GISTs differ histologically, immunohistochemically and genetically from leiomyomas, leiomyosarcoma and schwannomas. Fine needle aspiration can be used to diagnose GISTs as spindle cell and epithelioid types, but cytomorphology alone cannot be used to assess malignant potential. Immunocytochemical staining for CD117 is helpful in confirming the diagnosis. Care must be taken to differentiate epithelioid-type GISTs from adenocarcinoma. Surgery is the treatment of choice for resectable tumors. GISTs bear good prognosis after margin negative surgery. Tumor size and mitotic activity are best predictive prognostic features; small intestinal tumors behave more aggressively than gastric tumors with similar parameters [
A 70 year-old woman was admitted to hospital because of no defecation for 9 days and lower abdominal pain. Physical examination found abdominal distension and increasing peristaltic. Rectal examination find rectal polyp with diameter 8 cm the superior border not clear, colonoscopy cannot enter because of polyp mass.
Plain abdominal X-Ray (
1 week after this diagnostic we performed laparotomy exploration is shown in
The case of S 54-year-old woman with chief complain is left lower abdominal pain and mass, Melena for one week, and history of repeating transfusion on hospital because of anemia. Physical examination mass diameter 9 cm on left lower abdomen, hard consistency and tenderness, fix. Endoscopic with normal limit.
MSCT are shown in
USG mass diameter reduce become 7.28 × 3.59 cm (
A 20 year-old man was admitted to hospital because of urine retention and change bowel habit in 1 year, other complaints are frequent diarrhea since 1 year ago, sometimes defecation like goat droppings. Digital rectal sphincter tone obtained in the normal range, no enlarged prostate, no prostate nodules, palpable mass ekstralumen 1 - 6 o’clock direction, at a distance of 3 cm from the anal verge, the rectal mucosa slippery, and you do not get blood, mucus in handschoen. CEA within normal limits.
Examination of multislice CT scan are shown in
There does not appear infiltration into the surrounding mass and enlarged lymph nodes and paraaorta and parailiaca. Examination guiding FNAB performed well with CT scan, the results of FNAB of the mass of pelvic cavity is spindle tumor mesechymal. colonoscopy with normal mucosa results. Caecum, colon ascendens, transverse colon, colon descenden, rectosigmoid not found mass, ulcer, erosions, polyps and diverticular. Patients also performed USG (
Surgery performed with Milles procedure, found retrorektal tumor mass diameter of 10 cm that invasive on the rectal wall (
Colorectal GISTs are rare, frequency being reported at approximately 5%, we just found three cases in 2 years, two localized at rectal and the other at descending Colon .Gist defined as cellular spindle cell, epithelioid, or pleomorphic mesenchymal tumor of the gastrointestinal (GI) tract, the term gastrointestinal stromal tumor
(GIST) was introduced by Mazur and Clark in 1983 to differentiate GISTs from leiomyoma [
According to all larger clinicopathologic series, GISTs have a predilection to adults over 50 years of age, with the median ages varying between 55 - 65 years in different sites with no clear sex predilection. Our study, 2 case over 50 years old and one case 20 years old, The proportion of patients under 40 years have ranged between 5% and 20% in the larger clinicopathologic series [
Histological subtypes of GISTs include spindle, epithelioid or mixed cell tumors. In our surgery the histologi of three cases is myxoidlipo sarcoma, mesenchymal tumor, and gastro intestinal stromal tumor (GIST). The mass may be smooth or multinodular contour, containing central areas of hemorrhage, cystic change, necrosis or calcification. Even if the synchronous occurrence of GIST and Colorectal adenocarcinoma is not extremely rare, little is known about their potential common origin and carcinogenetic pathways [
All cases we have presented had size more than 5 cm are considered as unfavorable prognostic factors to Fletcher criteria (
Surgical resection, for rectal gist performed low anterior resection and milles, descending colon GIST performed left hemicolectomy was performed for the only treatment. patients have no remained chief complain for several months after surgery and no recurrence has been observed, but one patient post milles with urinary incontinence complaints found and that patients trained to CIC (intermittent catheterization). The prognosis of GIST is aggressive and complete surgical for this reason, enbloc resection without tumor rupture is the treatment modality [
GISTs are usually slow growing lesions, and are often incidentally discovered. Tumor size, location and growth pattern are associated with symptomatic presentation. Tumors smaller than 2 cm are often asymptomatic, usually limited to the colonic wall and appearing as submucosal masses in endoscopic studies. But in all our cases is advance size the smaller diameter is 8 cm, obstruction and abdominal pain is the most common complication. Tung-Cheng write that the most common symptoms of rectal GIST are tenesmus and lower GI bleeding, which are similar to those of other kinds of rectal tumors [
Immunohistochemically, GISTs are usually positive for KIT (CD117), a transmembrane receptor that is normally expressed on the myenteric plexus of the normal adult, among others tissues. All our cases immunocytochemical staining for CD117 is Positive. Approximately 70% of GISTs coexpress CD34, and they also may be positive for smooth muscle actin and rarely for desmin and S-100 protein. However, the term GIST is only applied to gastrointestinal mesenchymal neoplasms witch are c-kit positive, with rare exceptions. Approximately 95% of GISTs are positive for expression of the KIT (CD117, stem cell factor receptor) protein and as well as 70% - 80% of GISTs expressing CD34, the human progenitor cell antigen [
Risk to Gastrointestinal Stromal Tumors | ||
---|---|---|
Size (cm) | Mitotic Count (per 50 HPF*) | |
Very Low Risk | <2 | >5 |
Low Risk | 2 - 5 | <5 |
Intermediate Risk | <5 | 6 - 10 |
5 - 10 | <5 | |
Hight Risk | >5 | >5 |
>10 | Any | |
Any | >10 |
*HPF: Hight-Power Field. The Korean Journal of Pathology [
or size more than 5 cm are considered as unfavorable prognostic factors. The mitotic counts in GISTs vary in numbers from 0 - 20 per 50 HPF, and high mitotic counts are rare; the mitotic count is one of the most important histologic predictors of malignancy [
Anatomic location has been previously proposed as a prognostic factor independent of tumor size or mitotic rate. In this sense, small bowel tumors have been associated with the worst prognosis, while other authors have regarded most esophageal and colonic lesions as malignant. Unfortunately, tumor localization is not reliable in predicting outcome for each individual case. Because of some GISTs can recur or metastasize despite a histologically benign appearance, GISTs has been stratified into very low, low, intermediate and high-risk categories according to Fletcher criteria (tumor size and mitotic count). Actually, an indefinite follow up period has been suggested. Surgery is the standard treatment for localized primary disease without metastatic involvement, with a 5-year survival range from 45% to 65%. Endoscopic resection could be an option if technically feasible by tumor size or location but in our second case the rectal polyp size is the huge (
Liver and peritoneum are the most common metastatic sites in malignant GISTs. Lymph node metastases are very uncommon, in our second case have mesenterial node metastases. Glivec (Imatinib®), a tyrosine kinase inhibitor, has been used with good results in metastatic or unresectable GISTs. Postoperative imatinib treatment is recommended if the tumor is removed grossly, but the operative specimen has positive microscopic margins, designated as R1 resection, or if a gross visible tumor was left behind designated as R2 resection. Observation is all that is recommended if an R0 resection (negative microscopic margins) was achieved. The consensus at this time is to treat patient in a multidisciplinary approach based on biopsy margin, tumor size, mitotic rate, site, immunohistochemical staining, and mutational status [
Colorectal GIST is very rare and can present as mass abdomen. Complete resection with an aggressive attempt to remove all gross disease and achieve negative margins remains the fundamental surgical principle in the management of GIST. Most of GISTs are positive for expression of the CD117. Postoperative imatinib treatment is recommended.
Yuda Handaya,Sutamto Wibowo,Iwan Kristian, (2016) Management Colorectal Gastrointestinal Stromal Tumors (Gists) in Surabaya. Open Journal of Gastroenterology,06,97-105. doi: 10.4236/ojgas.2016.64013