The paper defined acquired immune deficiency syndrome (AIDS) as a hematological abnormality rather than a clinical abnormality. Viruses that cause AIDS in man and animals are reviewed. Suggestion that <i>human immune deficiency virus</i> (HIV) which causes HIV/AIDS in man is a mutant of <i>simian immune deficiency virus</i> (SIV) which causes SIV/AIDS in nonhuman primates is also re-viewed. For a simple test to enable researchers in the developing countries which have the highest incidences of HIV/AIDS, join the global search for more effective treatment for the pandemic, direct passive hemagglutination test has been developed for <i>in vitro</i> testing of drugs, herbs and minerals that may have antiretroviral effects. Also reviewed are the similarities in pathogenesis of HIV infection in man and pathogenesis of <i>infectious bursa disease virus</i> (IBDV) in chicks to assess possibility of developing vaccine for HIV/AIDS. Finally, antiretroviral effects of medicinal synthetic aluminum-magnesium silicate as cure for HIV/AIDS were reviewed.