Objective: To report an unusual case of pyriform sinus-pleural-mediastinal fistula secondary to internal penetrating trauma by a toothbrush, with emphasis on management options. Case report: A 26-year-old woman swallowed a toothbrush in a violent manner 8 months ago in an attempt of self-mutilation. She immediately complained of neck pain and dysphagia. She was diagnosed with pyriform sinus-pleural-mediastinal fistula. The fistula was repaired. Primary closure was performed and covered with the sternocleidomastoid muscle flap, and reinforced with thyroid tissue and surrounding tissues. The patient did not present any complications or recurrence, and she gained weight after the operation. Conclusion: Early recognition of hypopharyngeal perforation is important, and in selected cases, immediate repair of the perforation can lead to a good prognosis.
Perforation of the hypopharynx is a rare injury, accounting for less than 2% of all perforations in the pharynxgoesophageal region [
A 26-year-old woman swallowed a toothbrush in a violent manner 8 months ago while attempting self-mutilation. She immediately complained of neck pain and dysphagia. Conservative treatment was applied without any improvement in the local hospital. The patient was then treated with debridement and drainage of a neck abscess, mediastinal abscess, and thoracic close drainage, as well as repair of pyriform sinus perforation with the greater omentum 7 months ago. Jejunostomy was also performed at the same time. However, pyriform sinus perforation recurred 1 week later. A hypopharynx stent implantation was then performed, but the patient forced the stent out by herself. The patient was then transferred to our hospital and admitted with the diagnosis of pyriform sinuspleural-mediastinal-fistula and empyema.
A physical examination showed that her temperature was 36.5˚C, her pulse was 76/min, respiration was 20/min, and blood pressure was 97/61 mmHg. The patient exhibited cachexia and an anemic appearance. The right side of the thorax was slightly collapsed with an external thoracic drainage tube and weak breathing sounds. A nutrient canal was placed in the abdomen. A routine blood test showed the following: white blood cell count, 7.9 G/L; neutrophilic granulocytes, 60.25%; and Hb, 6.9 g/L. An electrocardiogram showed sinus tachycardia (116/min) with right axis deviation. Chest X-ray films and visualization of the esophagus with iodized oil showed right pleural thickening with adhesions, encapsulation, and pneumatosis in the chest wall, and pyriform sinus-pleural-mediastinal fistula (
Under gastroscopy, we found a fistula opening at the bottom of the right pyriform sinus, below the level of the arytenoid cartilage and close to the esophageal entrance (
changes of chest drainage, accompanied by collapse of the right thorax. Local consolidations in the superior and inferior lobes of the right lung were observed (
The patient was given surgical treatment. The neck was opened with an anterior incision parallel to the sternocleidomastoid muscle, and the pharynx and esophagus were mobilized from the prevertebral fascia. The fistula was repaired. Primary closure was performed, and covered with the sternocleidomastoid muscle flap and reinforced
with thyroid tissue and surrounding tissue. A nasogastric tube was placed and a drainage tube was inserted into the incision. Postoperatively, the patient was given intravenous antibiotics and best support care. The jejunal feeding tube was removed within 24 hours after the operation and replaced by nil per os for 10 days. After 48 hours, the cervical drainage tube was removed without drains from the tube. The patient began to receive a semi-liquid diet orally on the 10th day after the operation, and the thoracic drainage tube was removed at the same time. On the 14th day after the operation, the nasogastric tube was also removed and visualization of the esophagus with iodized oil was performed again. This showed contrast agent extravasation from both sides of the pyriform sinus into the trachea without leakage, which indicated intact hypopharyngeal repair (
The most common sites of hypopharyngeal perforation are the weak posterior hypopharyngeal wall and pyriform sinus. The pyriform sinus is well covered with muscle, which is comparatively resistant to penetration because of its strong extensibility [
Once pyriform sinus perforation occurs, symptoms in the early stage may be mild, such as neck pain, limitation of cervical motion, odynophagia, hoarseness, dyspnea, subcutaneous emphysema, and mediastinal emphysema. Later clinical manifestations with fever and local swelling may be indicative of retropharyngeal or parapharyngeal abscess or severe complications, such as mediastinitis, neck abscess or fistula, and pyriform sinuspleural-mediastinal fistula, where the prognosis is directly related to delays in diagnosis or management [
Rapid diagnostic tests are required for suspected perforation, and an X-ray should be performed first. X-rays often reveal signs of subcutaneous or mediastinal emphysema, as well as pleural effusion. However, the results from plain X-rays are sometimes negative, which is insufficient to rule out perforation. In this case, contrast X-ray studies provide confirmation of perforation and information about its location and extent. In some cases, visualization of the esophagus with iodized oil may lead to missed diagnosis of perforation with a false negative rate of 25% - 50%. If the diagnosis cannot be confirmed using contrast X-ray, an esophageal barium meal should be performed because of its higher sensitivity, especially in small tears or perforations [
The treatment of pyriform sinus perforation remains controversial. Physicians should be aware of this type of lesion, and the diagnosis should be confirmed and the patient properly treated as early as possible. Treatment, including conservative treatment and surgical intervention, depends on the situation of perforation, such as the size of injury, cause, site, complications, and patient’s age and physical condition. Conservative treatment of pyriform sinus perforation consists of nil per os, intravenous broad-spectrum antibiotics, and either gastric or parenteral nutrition. Surgical intervention includes neck drainage, chest or upper mediastinal drainage, and transoral endoscopic or surgery repair. Currently, it is recommended that conservative treatment is suitable for the following patients suffering from pyriform sinus perforation [
Pyriform sinus perforation is a type of hypopharyngeal perforation. In our case, perforation caused by a toothbrush accompanied by pyriform sinus-pleural-mediastinal fistula is an extremely rare injury. Early diagnosis is particularly important. The therapeutic options depend on the complications and the patient’s condition. Close observation is also essential. Mortality and prognosis are directly related to delays in diagnosis and treatment.
1) Hypopharyngoesophageal perforation develops rapidly, easily leading to serious complications. If early conservative treatment fails, surgical repair should be followed as soon as possible.
2) The key to treatment of this lesion is to be aware of its possibility, as well as to confirm the diagnosis and treat the patient properly as early as possible.
3) Simple sutures are difficult to heal because of insufficient blood supply to the hypopharynx. Muscle flap coverage allows an increase in local blood supply, enhancing immunity and reducing friction and compression of surrounding tissue. The sternocleidomastoid is recommended for closure of hypopharyngoesophageal perforations, which was applied in our patient to repair pyriform sinus perforation. The muscle flap needs to be snugly placed.
4) Enhancement of blood supply to the surrounding tissue is important. In our patient, the repair was reinforced with thyroid tissue and surrounding tissue.