Pancreatic pseudocyst-portal vein fistula

Open Journal of Gastroenterology
Vol.2 No.3(2012), Article ID:22043,2 pages DOI:10.4236/ojgas.2012.23028

Pancreatic pseudocyst-portal vein fistula

Kei Horino, Hiroshi Takamori, Yoshiaki Ikuta, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu, Hideo Baba*

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

Email: *hdobaba@kumamoto-u.ac.jp

Received 29 April 2012; revised 16 June 2012; accepted 28 June 2012

Keywords: Pancreatic Pseudocyst; Fistula; Pancreatitis; Portal Vein; Drainage

ABSTRACT

Pancreatic pseudocyst-portal vein fistulae are extremely rare, and cause serious complications, including life-threatening sepsis. We report a 57-year-old man with pancreatic pseudocyst who was admitted to our hospital complaining of prolonged abdominal pain. A pancreatic duct tube was placed into the main pancreatic duct, as the pseudocyst was communicated to the pancreatic duct. He fell into septic shock state two weeks later. An ultrasonography-guided percutaneous drainage of the pseudocyst was performed. The amylase level of drained pus was 80,000 U/l. Pancreatic pseudocyst-portal vein fistula was demonstrated by fisterography. Symptoms disappeared immediately after drainage. No recurrence was observed afterward.

1. INTRODUCTION

Pancreatic pseudocysts are well known as common complications of acute or chronic pancreatitis and complicate the course of chronic pancreatitis in 30% to 40% of patients [1-3]. However there have been few reports of pancreatic pseudocyst-portal vein fistulae that cause serious complications, including life-threatening sepsis. We report the case of a patient with a pancreatic pseudocystportal vein fistula required percutaneous drainage as a treatment for the sepsis.

2. CASE REPORT

A 57-year-old man was admitted to Kumamoto University hospital complaining of prolonged upper abdominal pain. He had been diagnosted as a chronic panceratitis with a history of heavy alcohol use. Ultrasonography, endoscopic retrograde cholangiopancreatograpy and CT (Figure 1) demonstrated the pancreatic pseudocyst-portal vein fistula with portal thrombosis. As a first treatment, an endoscopic retrograde pancreatic duct tube was placed into the main pancreatic duct. We observed the pseudocyst was communicated to the pancreatic duct. He suffered from septic shock with enterococcus in blood culture two weeks later. Because septic state was not improved by the conservative treatment with antibiotics and CT revealed that the pancreatic pseudocyst was increasing, ultrasonography-guided percutaneous drainage into the pseudocyst was performed. An amount of 40 ml of pus was drained. The amylase level of this fluid was 80,000 U/l. Fisterography demonstrated the pancreatic pseudocyst connected to the portal vein (Figure 2). Both high fever and upper abdominal pain disappeared immediately. A CT performed three weeks later demonstrated a significant reduction of the pseudocyst. Neither recurrence of abdominal pain nor fever was observed afterward.

3. DISCUSSION

Only 17 cases of pancreatic pseudocyst connecting with the portal venous system have been reported [4-6]. Several reports indicated that activated pancreatic enzymes in the pseudocyst might cause inflammation and directly

Figure 1. Abdominal computed tomography: the pancreatic pseudocyst-portal vein fistula (white arrow) with thrombosis.

Figure 2. Fisterography: the pancreatic pseudocyst connected to portal vein (black arrow).

contribute to cyst wall fragility and failure. These enzymes also cause erosion of the portal wall and induce venous thrombosis [4,7]. Spontaneous rupture of the pancreatic cyst occurred in about 5% of patients [7]. Most patients suffering from pancreatic pseudocyst-portal vein fistulae are asymptomatic or complained of mild abdominal pain. However, some patients have severe, life-threatening complications, such as massive bleeding in the digestive tract, septic shock, disseminated fat necrosis and intramedullary bone necrosis [4].

In this case report, we report a case of pancreatic pseudocyst-portal vein fistula in which the patient fell into septic shock state, which was improved by Ultrasonography-guided percutaneous drainage.

REFERENCES

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NOTES

*Corresponding author.