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chemistry searched first to define the inner composition
of samples of inert matter most calling the attention of
human society. Latter arrived to define the chemical
structure of organic compounds of importance for life.
Urea, Penicillin and Insu lin name three of the early great
efforts. These are some among the first milestones of
chemical synthesis together with Chlorophyll.
With the progressive development of biochemistry, in
the last century, the chemistry of life has started to show
the immense variety of molecular compositions with
higher sense, utility and possibly finality. In some case
the simplicity of the solution by nature of the utmost
complex task had some biochemists saying to the chem-
ists:
Do you think that such enormous beauty of molecule
would have been arrived at, just by chance, necessity and
of natural blind evolution?
In the next decades of the 21st siècle chemical sci-
ences could reach however the right molecules to control
definitively diseases without secondary toxicities by
chemicals so far of impossible synthesis in the laboratory.
Of course, first in humans and after in those animals and
vegetables more related to our society. I think that the
Earth could arrive in few centuries to collaborate with
the unicellular beings of phytoplankton and zooplankton.
These are the massive and important components of life
in our planet for the permanence of life and humanity at
large.
4. “IMPOSSIBLE” CHEMICAL
SYNTHESIS?
I think that the better conditions for chemical synthesis
invented by Nature are shown by the living cells and
organisms. There are many thousands different type of
cells for different tasks, either as single organisms, cel-
lular aggregates or forming the tissues of a more com-
plex living beings. For impossible chemical synthesis for
our present technology I propose to copy as properly as
possible the living cells conditions for synthesis of
chemical biological molecules.
What are essentially these conditions?
They are very varied. Life can perform chemical syn-
thesis of complex molecules from very low to very high
temperatures. In the complete darkness or with the con-
course of light. In very varied atmospheric gas conditions,
nutrient´s availability, as it is adequate for survival and
adaptability including incredible levels of salinity or
methane concentration.
My group studied, decades ago, an assortment of
complex chemical compounds in its inhibitory effect in
rodent mitochondria, extracted and purified from plants
of the Canary Islands [5,6]. Many of these chemical
structures caused a complete reverence for Mother Na-
ture capacities for chemical synthesis in plants, even to
experts in natural compounds.
One of the important things to mention is that the liv-
ing cell interior’s constitute a “soup very heavy”. Even
water concentration, that is the more abundant simple
component of the living cell, rounds 55 Molar in the liver
rodent cells. Therefore as the pressure of ambient com-
pounds in this interior is very variegated the competing
enzymes must be very specific. The succession of pre-
cursor molecules of the compound aimed must be spe-
cifically tailored for the final task. The due thinking of
this concept needs a careful joinin g of the more co mplete
experience in biological and organic chemical synthesis.
5. POSSIBLE SUGGESTIONS FOR
ADVANCED CHEMICAL
SYNTHESIS?
I would suggest to try chemical synthesis in very thick
mesophases, changing amply the pressure, magnetic field,
temperature variations, ambient compounds, gases and
enzymes as need for the tasks programmed. The enzymes
first should be of vegetables or from unicellular beings,
those already known and perhaps the majority to be
searched in the next decades. Many other things could I
tell if counting with an appropriate collaboration in a
international economical effort to copy, doing things first
very artificially, life’s incredible simplest molecules with
great benefit for the future curative pharmacology of all
of us together better health
6. A CONCISE DEFINITION OF
“IMPLEXES”
Instead of linking a metal with adequate chemical che-
lating forceps, please try to embrace it, and leave it freely
in its “Molecular Nest”. With it being capable of course
to react by, let us say, at this early step of my stuttering
thinking: Chemical Resonance.
To say, any word more in this step will compromise
the presentation of a generic patent by the main Indus-
tries possibly interested in this new research adventure.
This is not a journal to use cryptic chemical quantum
physics notions to disguise things to experts somewhat
lesser advanced in chemistry. Let however end with a
tender blink of my left eye:
“Chemical pertaining does not necessarily require
chemical bonds and can lead to a set forming part of one
set, or two sets, or more sets. It seems a contradiction but
perhaps these are situations very common in Life’s As-
tonishing Perfections” in my regard.
REFERENCES
[1] Gosalvez, M. (2013) Reversal of cancer by dual strategy?
Journal of Cancer Therapy, 4, 518-520.
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