Primary Cervical Choriocarcinoma: Case Report and the Review of Literatures
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Chetrit [18]. Necrosis is a predominant feature of these
neoplasms, often to such an extent that the viable tissue
is obscured. So, we should consider immunohistochemi-
cal staining in extend necrotic tissue obtained from cer-
vix for more information, because there is the chance for
more limited surgery and more successful chemotherapy
for choriocarcinoma if it is diagnosed in the first step. In
our case, massive necrosis of the tumor and arising of
tumor from non-epithelial origin motivate the pathologist
to perform immunohistochemical staining. As we show-
ed the specimen was markedly positive fo r B-hCG.
The treatment of choice as in our patient was total ab-
dominal hysterectomy and bilateral salpingoopherectomy
with or without chemotherapy. In terestingly, Ben-Chetrit
and his co-worke rs in one report and Roopnarinesingh et
al. in other report, documented conservative management
of primary cervical choriocarcinoma [4,18].
5. Conclusion
In conclusion, cervical choriocarcinoma should be con-
sidered in the differential diagnosis of cervical lesions in
their child-bearing years, especially lesions with promi-
nent vascularity. A beta-hCG assay, transvaginal color
Doppler sonography or contrast-enhanced MRI may
form part of pre-operative investigation in such a patient.
A detailed correlation between histologic findings and
patient’s clinical history, lab studies and radiologic data
is always required to preclude diagnostic pitfalls and de-
signates the appropriate treatment.
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