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Engineering, 2012, 5, 124-125 doi:10.4236/eng.2012.410B032 Published Online October 2012 (http://www.SciRP.org/journal/eng) Copyright © 2012 SciRes. ENG Heart and Lung Mechanical Assist Devices are Comprehensively Tested by the New Hybrid Simulators M. Darowski1, K. J. Pałko1, M. Kozarski1, K. Zieliński1, K. Górczyńska1, G. Ferrari2, L. Fresiello2, A. Di Molfetta2 1Nałęcz Institute of Biocybernetics and Biomedical Engineering, PAS, Ks. T r o j de n a 4, 02-109, Warsaw, Poland 2Inst itut e of Clinical Physiolog y, Section of Rome, CNR, Via Sa n Martin o della Battaglia 44, 00185, Rome, Italy Email: mdar@ibib.waw.pl Received 2012 ABSTRACT Two applications of the hybrid simulators have been presented as examples: nonpulsatile VAD interaction with lumped parameters cardio vascular syst em numeric al model an d resp irator inter acting with th e Dubois nu merical model of obstru ctive lung diseas es. Th e results of simulations showed how the tested assist devices change biological system - assist device characteristics in the course of heart or lungs diseases and how it influences pressure and flow in a particular point of cardiovascular or respir atory system numerical model. Keywords: Ventricular Assist Device; Respirator; Modelling; Hybrid Simulator 1. Introduction Different type of heart and lung support systems and devices like ventri cular assist devices (VAD) and r espirators have been developed up to now but the problem how to test them, objec- tivel y, compare their features - advan tages and disad vantages is still to be solved [1-3]. The heart and lung assist devices are, generally speaking, mechanical pu mps th at shou ld be tested befor e th eir clin ical use, according to appropriate standards. In order to access the fea- tures of these devices it is necessary to connect them to me- chanical models of the biological organ or system (the human circulatory or respiratory systems) that are to be assisted or supported. Such mechanical models of the human circulatory or respiratory systems are expensive, as they have to be complex to simulate different pathologies of the biological (cardiovas- cular or respiratory) systems. Computer models of the human cardiovascular or respiratory systems are much cheaper th an the mechanical on es but, on the other hand, they can not be connected with mechanical assist devices like blood pumps or respirators [4,5]. 2. Materials and Methods The solution we propose to test heart and lung assist devices is to use a new type of simulators (patent pending) – so called hybrid ones. They consist of a computer model of the human cardiovascular or respiratory system and a specially designed interface to connect this model with the mechanical assist de- vice. These interfaces (electro-hydraulic for VAD or elec- tro-pneumatic for respirators) play a role of impedance con- verters, as t hey enable to convert a part of the numerical model into a physical part o f the same impedan ce, to which the tested assist d evi ce is connected ( Fig ure 1). It was possible to realize this concept thanks to the applica- tion of electrically connected flow and/or pressure sources as basic components of the impedance converters (see Figures 2-3). There are varieties of technical realization of the impedance convert er. In a case of test ing the VAD we used a gear pu mp to build the voltage controlled flow source being a crucial part of the imped ance convert er (Figure 2) and in a case of testing t he respirators, a voltage controlled piston flow source was used as a basic co mponen t of the impedance conver ter (Figure 3). Figure 1. The idea of testing mechanical assist devices on a hybrid simulator of the cardiovascular or respiratory system. Fig ur e 2 . Set-up of the hydro-numerical interface (VAD-lef t a tr i um) for testing a nonpulsatile VAD on the hybrid simulator with a gear pump as a voltage controlled flo w source. M. DAROWSKI ET AL. Copyright © 2012 SciRes. ENG 125 3. Results Two applications of the mentioned above simulators have been presented as examples: nonpulsatile VAD interaction with lumped p arameters cardi ovascular syste m numerical model and respirator interacting with the Dubois numerical model of ob- structive lung diseases. The results of simulations showed how the tested assist devices change biological systems characteris- tics in the course of heart or lungs diseases and how it influ- ences pressure and flow in a particular point of cardiovascular or respirato ry system numerical model. The results of simulations of the cardiovascular system in- teracting with a nonpulsatile VAD were shown in Figure 4 as P-V loops. Modelling of physiological and pathological states of the cardiovascular system was done and in the case of pathology the VAD was applied as assist1 and assi st 2. As we can see fro m Figure 4, VAD application changes P-V loop location but not so dramatically as pathology of the car- dio vascular system. The results of simulations of the respiratory system interact- ing with a respirator are shown in Figure 5 as time curves of control (Pin) and pleural (Pt) pressures. The respirator is pro- viding pressure control ventilation of the human lungs which is a t ypical Du b oi s model with an ab stract ive lu ng d iseas e. As can be seen fro m Figure 5, thi s disease causes posi tive end expira- tory pressure to appear in the lungs. Figure 3. Set-up for testing a respirator on the hybrid simulator with a voltage controlled piston flow source. 0 20 40 60 80 100 120 140 160 050100 150 200 Vlv [cm 3 ] Plv [mmHg] phy siology pathology path+assist1 path+assist2 Figure 4. The results of simulations of the cardiovascular system interacting with a nonpulsatile VAD. 0 0,2 0,4 0,6 0,8 1 30 3540 45 time [s] pressur e [kPa] Pin Pt Figure 5. The results of simulations of the respiratory system inte- racting with a resp irator . 4. Conclusion Tests of the hybrid simulators performance and simulations of their interaction with heart and lung assist devices proved that they are reliable and accurate tools to test these devices and help to optimize their applications in different cases of heart and lungs pathology (as decision support systems). 5. Acknowledgements The resear ch leadin g to these resul ts has received fu nding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement No. 248763 (Senso- rART Project). REFERENCES [1] M. S. Slaughter, J.G. Rogers et al., “Advanced Heart Failure Treated with Continuous- Flow Left Ventricular Assist De- vice”, N. Engel. J. Med., vol. 361, pp. 2241-2251, December 2009. [2] K. Górczyńska, “Circulatory Assistance: Basic Classification of Heart Ass i st a nc e M eth od s an d Devi c es” , Bi oc ybern . and Bi om ed . Eng., vol. 31, pp. 3-15, January 2011. [3] S. Garcia, F. Kandar, A. Boyle, M. Colvin-Adams et al., “Ef fect of Pulsa tile and Cont inuous -flow Left Ven tricu lar Assis t Devic- es on Left Ventricular Unloading”, J Heart and Lung Trans., vol. 22, pp. 261-267, March 2008. [4] D. Morley, K. Litwak, P. Ferber, P. Spence, R. Dowling, B. Meyns et al., “Hemodynamic effects of partial ventricular sup- port in chroni c hea rt fai lure: R esult s of sim ulati on vali dat ed with in vivo da ta”, J. Thorac. Ca rdiol. Surg., vol. 133 , pp. 21-28, Jan- uary 2007. [5] K.W. Gwak, B.E. Paden, J.F. Antaki, I.S. Ahn, “Experimental Verification of the Feasibility of the Cardiovascular Impedance Simu lator”, IEEE Trans Biomed En g, vol. 57, pp. 1176-83, M ay 2010. |