Evaluation of Some Biological Activities of Albizia lebbeck Flowers
476
beck have analgesic activity but flowers extracts didn’t
take due attention [18]. For flowers extracts as shown in
the Table 2, a maximum of 25.7% increase in the reac-
tion time was shown by the dichloromethane extract. The
aqueous extract was inactive. Maximum increases in the
pain threshold were observed 90 minutes after admini-
stration of each extract.
4.3. Estrogenic Activity
Estrogens are steroid hormones with important functions
in the regulation of specific sexual processes in the fe-
male. It was reported that methanolic pod extract of A.
lebbeck has antifertility effect but nothing was reported
about estrogenic effect [19]. At a dose of 500 mg/kg I.P.
to immature rats, only total alcohol extract caused sig-
nificant increase in the ratio of weight of the two uterine
horns to the total body weight by 109.14%. This is a very
high percentage and indicates the potent estrogenic ac-
tivity of the total alcohol extract that can point to further
researches. Whereas, the ethyl acetate extract exerted
significant depression of uterine weight/body weight
ratio.
4.4. Anti-Inflammatory Activity
Screening of the anti-inflammatory activity of seeds and
bark of A. lebbeck was reported but nothing about flow-
ers of species growing in Saudi Arabia was reported
[17,18]. The best extract which showed anti-inflamma-
tory activity was the dichloromethane extract with 71.6%
followed by the ethyl acetate extract with 60.3% inhibi-
tors.
In conclusion, these findings clearly suggest that flow-
ers of Albizia lebbeck growing in Saudi Arabia have in-
teresting biological activities and we recommend further
research for isolation of the components responsible for
the estrogenic and anti-inflammatory activities.
5. Acknowledgements
This research project was supported by a grant from the
research Center of the Center for Male Scientific and
Medical Colleges in the King Saud University.
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