J. Shinwari et al. / Open Journal of Genetics 3 (2013) 171-173
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173
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Figure 2. Linkage disequilibrium plot (LD plot) showing a
strong linkage between marker 2 and 3 in the patient’s samples:
The numbers in the blocks represent multi-allelic D’ with
values ranging from 0 to 1(shown in percentage), Red squares
indicate statistically significant (LOD >2) allelic association
(linkage disequilibrium, LD) between pairs of markers, White
squares indicate D’ values of <1 with no statistically significant
evidence of LD, markers are numbered from 1 to 7 to the top.
breeding between groups with different alleles has dis-
torted the haplotype frequencies, causing linkage dis-
equilibrium [14].
Performing similar studies on a larger β-thalassemia
cohort would be essential for allowing the conduction of
a significant linkage between haplotypes and disease
causing mutations in the Saudi population.
5. ETHICAL APPROVAL
This work was approved by KFSHRC IRB, Research Advisory Council
(RAC) and Research Ethics Committee (REC) (RAC# 2080012).
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