Microbiologic and Clinical Comparison of Patients Harboring Escherichia coli Blood Isolates with and
without Extended-Spectrum β-Lactamases
53
producing isolates, other studies have not supported this
[9,15,16]. Additional studies have shown that increased
mortality was not statistically associated with ESBL pro-
duction or inappropriate therapy [10,12,16]. Differences
in outcome studies can be explained by associated vari-
ables including severity of illness of patients, comorbid
conditions, time to initiation of antibiotics, and virulence
factors associated with the organisms and may be inde-
pendent of ESBL production [10,12,16,17]. While physi-
cians should avoid broad-spectrum empiric therapy, con-
tinued surveillance and administration of carbapenems
should be considered as empiric therapy for patients with
bloodstream infections due to suspected ESBL positive E.
coli in our community [18].
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