P. J. Krizman et al. / J. Biomedical Science and Engineering 6 (2013) 185-191 191
cells Lipoic acid took care of antioxidant network and
protected lipid membranes by elimination of uncontrolled
oxidation which resulted in higher levels of CoQ10.
Nevertheless the correlations between measured and
calculated values were good, we were not able to con-
clude which previously described option was prevalent,
and further experiments are necessary.
4. CONCLUSION
Lipoic acid is the most potent member of antioxidant
protection in a body. With electric potential of (−320 mV)
it may regenerate all other antioxidants. Results undoubt-
edly confirm the existence of an antioxidant network and
synergistic effect of administered low weight substances.
Our work demonstrates that ALA is able to influence not
only on the regeneration of glutathione but according to
our results also on regeneration of CoQ10.
5. ACKNOWLEDGEMENTS
This work was supported by the Slovenian Research Agency (Research
Project L1-2174) and the Perutnina Ptuj, d.d.. The authors wish to
thank, Prof. Dr. Antonija Holcman and Prof. Dr. Marko Volk for their
support in experiments with animals.
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