A Case of CD34-Negative Superficial Acral Fibromyxoma
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cicular growth pattern, with myxoid stroma and promi-
nent vascularity [2,4]. It has been reported that the tumor
cells of the SAF are diffusely positiv e for CD34 and may
be focally positive for EMA, CD10, and CD99 [4,5-8].
In the present case, most of the tumor consisted of fi-
brous tissue with some areas showing m y xomatous change.
This is associated with the deposition of mucin among
the fibrous part. From these histological findings, we dia-
gnosed this tumor as SAF.
Immunohistochemical examination for CD34 was ne-
gative except for the endothelial cells within the tumor.
CD34-negative SAF has been reported previously [4],
and as supported by another example in the present case,
the diagnosis of SAF should not be made solely on the
basis of immunostaining for CD34.
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